紫杉醇联合卡铂方案同步放化疗在Ⅲ期胃食管结合部癌中的近期疗效和安全性  

Short-term Efficacy and Safety of Concurrent Chemoradiotherapy with Paclitaxel and Carboplatin in StageⅢGastroesophageal Junction Cancer

作　　者：吴仁瑞[1] 汪琛[1] 刘超[1] WU Ren-rui;WANG Chen;LIU Chao(Department of Oncology,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市人民医院肿瘤科,江西赣州341000

出　　处：《医学信息》2022年第20期52-55,共4页Journal of Medical Information

摘　　要：目的探讨紫杉醇联合卡铂方案同步放化疗在Ⅲ期胃食管结合部癌中的近期疗效和安全性。方法选择2019年8月-2021年10月赣州市人民医院收治的Ⅲ期胃食管结合部癌患者76例,根据随机数字表法分为研究组和对照组,每组38例。对照组给予紫杉醇+替吉奥单纯化疗方案治疗,研究组给予紫杉醇+卡铂同步放化疗方案。比较两组治疗前(T0)、治疗1个疗程后(T1)、治疗3个疗程后(T2)皮质醇(COR)、丙二醛(MDA)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、R0切除率、淋巴结阳性率、病理分期降期率、近期疗效及用药安全性。结果两组T1、T2时MDA水平低于T0,且研究组低于对照组(P<0.05);两组T1、T2时COR水平高于T0,但研究组低于对照组(P<0.05);两组T1、T2时NSE、CEA水平低于T0,且研究组低于对照组(P<0.05);研究组R0切除率、淋巴结阳性率、病理分期降期率均高于对照组(P<0.05);研究组DCR、RR均高于对照组(P<0.05);研究组药物毒副反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论Ⅲ期胃食管结合部癌中联合应用紫杉醇与卡铂方案同步放化疗的近期疗效理想,可减轻机体术后应激反应,降低肿瘤标志物水平,且不会大幅增加药物毒副作用,安全性较高。Objective To investigate the short-term efficacy and safety of paclitaxel combined with carboplatin concurrent chemoradiotherapy in stageⅢgastroesophageal junction cancer.Methods A total of 76 patients with stageⅢgastroesophageal junction cancer admitted to Ganzhou People's Hospital from August 2019 to October 2021 were selected and divided into study group and control group according to random number table method,with 38 cases in each group.The control group was treated with paclitaxel+tegafur chemotherapy alone,and the study group was treated with paclitaxel+carboplatin concurrent chemoradiotherapy.Cortisol(COR),malondialdehyde(MDA),neuron-specific enolase(NSE),carcinoembryonic antigen(CEA)before treatment(T0),after one course of treatment(T1)and after three courses of treatment(T2),R0 resection rate,lymph node positive rate,pathological stage downstaging rate,short-term efficacy and medication safety were compared between the two groups.Results The MDA levels at T1 and T2 in the two groups were lower than those at T0,and the study group was lower than the control group(P<0.05).The levels of COR at T1 and T2 were higher than those at T0,but the study group was lower than the control group(P<0.05).The levels of NSE and CEA at T1 and T2 in the two groups were lower than those at T0,and those in the study group were lower than the control group(P<0.05).The R0 resection rate,lymph node positive rate and pathological staging downstaging rate of the study group were higher than those of the control group(P<0.05).DCR and RR in study group were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the study group and the control group(P>0.05).Conclusion The short-term efficacy of concurrent chemoradiotherapy with paclitaxel and carboplatin in stageⅢgastroesophageal junction cancer is ideal,which can reduce the body's postoperative stress response,reduce the level of tumor markers,and will not significantly increase drug side effects,with

关 键 词：胃食管结合部癌 紫杉醇 卡铂 同步放化疗 应激反应 

分 类 号：R735.2[医药卫生—肿瘤]