角膜神经改变与干眼的研究进展  

Advances on the corneal nerve changes and dry eye

作　　者：丁一 郝然 王嘉瑢 李学民[2] Yi Ding;Ran Hao;Jiarong Wang;Xuemin Li(Undergraduate,School of Oncology,Capital Medical University,Beijing 100038,China;Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China;School of Life Sciences,Capital Normal University,Beijing 100089,China)

机构地区：[1]首都医科大学附属北京世纪坛医院,首都医科大学肿瘤医学院,100038 [2]北京大学第三医院眼科,100191 [3]首都师范大学生命科学学院生物科,100089

出　　处：《中华眼科医学杂志（电子版）》2022年第4期242-246,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：首都卫生发展科研专项项目(首发2018-2-4093)。

摘　　要：角膜表面具有丰富的神经末梢,是人体全身中最敏感的部位之一,对外界刺激反应迅速且强烈。干眼是一种复杂的多因素疾病,其症状与体征的变化及其严重程度不相符,诊断和治疗难度极大。近年来,有关干眼与角膜神经关系的研究备受关注;同时患有其他系统疾病者亦有眼干症状,表现为角膜神经改变。这对全身疾病的诊断和治疗有重要意义。因此,本文中笔者从角膜神经改变角度阐述开发干眼治疗和全身疾病进展监测方法的可行性。The cornea surface is rich in nerve endings,which is one of the most sensitive parts of human body.It responds very quickly and strongly to the external stimuli.As a complex and multifactorial disease,the severity of symptoms and signs of dry eye disease is inconsistent,which causing to make the diagnosis and treatment of the disease harder.In recent years,the relationship between dry eye and corneal nerve has been paid more attention.Meanwhile,patients with systemic diseases have dry eye symptoms,characterized by corneal nerve changes,which is of great significance for the diagnosis and treatment of systemic diseases.Therefore,the feasibility of dry eye treatment and monitoring the progress of systemic diseases is expounded from the perspective of corneal nerve changes in this paper.

关 键 词：干眼 角膜神经 角膜神经纤维密度 监测 

分 类 号：R777.34[医药卫生—眼科]