宫颈癌术后尿路感染对TGF-β1/Smads信号通路及预后的影响  

Influence of postoperative urinary tract infection on TGF-β1/Smads signaling pathways and prognosis of cervical cancer patients

作　　者：何科[1] 袁林静 牛刚[1] 潘文威 瞿虎[2] HE Ke;YUAN Lin-jing;NIU Gang;PAN Wen-wei;QU Hu(The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510080,China;不详)

机构地区：[1]中山大学附属第一医院妇产科,广东广州510080 [2]中山大学附属第六医院泌尿外科,广东广州510080

出　　处：《中华医院感染学杂志》2022年第17期2689-2693,共5页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金(8170100302)。

摘　　要：目的探究宫颈癌患者术后尿路感染对转化生长因子β1(TGF-β1)/Smads信号通路及预后的影响。方法选取2018年1月-2021年4月中山大学附属第一医院收治的宫颈癌术后发生尿路感染患者109例为研究组,同时募集同期宫颈癌术后未发生尿路感染的患者90例为对照组,比较两组患者血清白细胞介素(IL)-6、IL-1β、肿瘤坏死因子(TNF)-α及TGF-β1水平,实时荧光定量聚合酶链反应(PCR)法检测外周血TGF-β1、TGF-β受体1(TGF-βR1)、Smad6及Smad7 mRNA水平,并分析两组患者预后。结果研究组患者血清IL-6、IL-1β、TNF-α、TGF-β1及外周血TGF-β1 mRNA水平高于对照组,TGF-βR1、Smad6及Smad7 mRNA水平低于对照组(P<0.05),IL-6、IL-1β、TNF-α、TGF-β1及外周血TGF-β1 mRNA随感染程度加重而升高(P<0.05),TGF-βR1、Smad6及Smad7 mRNA水平随感染程度加重而降低(P<0.05);研究组患者留置尿管时间(12.68±3.52)d、术后住院时间(22.34±5.76)d及住院费用(3.31±0.98)万元均高于对照组(P<0.05)。结论宫颈癌术后尿路感染可加剧TGF-β1/Smads信号通路的活化,可能与患者血清细胞炎症因子升高有关,并严重影响其术后恢复。OBJECTIVE To explore the influence of postoperative urinary tract infection on transforming growth factorβ1(TGF-β1)/Smads signaling pathways and prognosis of patients with cervical cancer.METHODS Totally 109 cervical cancer patients who had postoperative urinary tract infection and were treated in The First Affiliated Hospital of Sun Yat-sen University from Jan 2018 to Apr 2021 were assigned as the study group,meanwhile,90 cervical cancer patients who did not have postoperative urinary tract infection were chosen as the control group.The levels of serum interleukin(IL)-6,interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and TGF-β1 were compared between the two groups of patients,the levels of peripheral blood TGF-β1,TGF-βreceptor 1(TGF-βR1),Smad6 and Smad7 mRNA were detected by real-time fluorescent quantitative polymerase chain reaction(PCR),and the prognosis of the two groups of patients was observed.RESULTS The levels of serum IL-6,IL-1β,TNF-αand TGF-β1 as well as peripheral blood TGF-β1 mRNA level were significantly higher in the study group than in the control group,while the levels of TGF-βR1,Smad6 and Smad7 mRNA of the study group were significantly lower than those of the control group(P<0.05).The levels of IL-6,IL-1β,TNF-α,TGF-β1 and peripheral blood TGF-β1 mRNA were significantly elevated with the aggravation of infection(P<0.05),while the levels of TGF-βR1,Smad6 and Smad7 mRNA were reduced with the aggravation of infection(P<0.05).The urinary catheter indwelling time and postoperative length of hospital stay of the study group were respectively(12.68±3.52)days and(22.34±5.76)days,longer than those of the control group;the hospitalization cost of the study group was(3.31±0.98)ten thousand yuan,significantly greater than that of the control group(P<0.05).CONCLUSION The postoperative urinary tract infection may aggravate the activation of TGF-β1/Smads signaling pathways in the cervical cancer patients,which may be associated with the rise of serum inflammatory factors and affect

关 键 词：宫颈癌 术后尿路感染 转化生长因子β1/Smads信号通路 细胞因子 预后 

分 类 号：R737.7[医药卫生—肿瘤]