纤维蛋白原/前白蛋白比值与非小细胞肺癌预后的相关性研究  

Correlation between Fibrinogen/Prealbumin Ratio and Prognosis of Non-small Cell Lung Cancer

作　　者：罗琳琳[1] 黎荣 方晓琳[1] 杨丽兰 郭猷殚[1] 喻杰[1] 章婷[1] 李环羽[1] LUO Linlin;LI Rong;FANG Xiaolin;YANG Lilan;GUO Youdan;YU Jie;ZHANG Ting;LI Huanyu(Jiangxi Provincial People’s Hospital,Nanchang 330006,China)

机构地区：[1]江西省人民医院(南昌医学院第一附属医院),江西南昌330006 [2]江西省萍乡市疾病预防控制中心

出　　处：《中国医学创新》2022年第33期21-25,共5页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(20195006)。

摘　　要：目的:探讨纤维蛋白原/前白蛋白比值(FPR)与非小细胞肺癌预后的相关性。方法:回顾性分析2012年1月-2015年12月江西省人民医院收治的126例非小细胞肺癌患者的临床资料。随访5年,按照是否发生死亡事件将患者分为存活组和死亡组,存活组36例,死亡组90例。收集患者基本特征、肿瘤最大直径、生化指标特征等信息,分析FPR与非小细胞癌预后的关系。采用ROC曲线判定FPR预测非小细胞肺癌患者预后临界值,采用COX回归分析非小细胞肺癌患者预后的影响因素。结果:非小细胞肺癌患者5年生存率为28.6%(36/126)。经多因素COX回归分析,吸烟、淋巴转移、肿瘤最大直径≥3 cm、FPR增高是影响非小细胞肺癌患者预后的独立危险因素(P<0.05)。将患者FPR水平按照ROC曲线预测的最佳临界值30.36分为两组,FPR高水平组患者5年生存率为2.0%(1/50),低水平组患者5年生存率为46.1%(35/76)。经log-rank χ^(2)检验,两组5年生存率比较,差异有统计学意义(log-rank χ^(2)=57.908,P<0.001)。结论:FPR是非小细胞肺癌患者预后的独立影响因素,可预测非小细胞肺癌患者的生存状态。Objective:To investigate the correlation between fibrinogen/prealbumin ratio (FPR) and prognosis of non-small cell lung cancer.Method:The clinical data of 126 patients with non-small cell lung cancer admitted to Jiangxi Provincial People’s Hospital from January 2012 to December 2015 were retrospectively analyzed.They were followed up for 5 years and divided into survival group and death group according to the occurrence of death events,including 36 cases in survival group and 90 cases in death group.Basic characteristics,tumor maximum diameter,biochemical indexes characteristics and other information of patients were collected to analyze the relationship between FPR and prognosis of non-small cell lung cancer.ROC curve was used to determine the cut-off value of FPR for predicting the prognosis of patients with non-small cell lung cancer,COX regression analysis was used to analyze the prognostic factors of non-small cell lung cancer.Result:The 5-year survival rate of patients with non-small cell lung cancer was 28.6% (36/126).COX multivariate regression analysis showed that smoking,lymphatic metastasis,tumor maximum diameter≥3 cm and increased FPR were independent risk factors for prognosis in patients with non-small cell lung cancer (P<0.05).The FPR level of patients was divided into two groups according to the optimal cut-off value of 30.36 predicted by ROC curve.The 5-year survival rate of patients with high FPR level was 2.0% (1/50),and that of patients with low FPR level was 46.1% (35/76).log-rankχ^(2) test showed that there was significant difference in 5-year survival rate between the two groups (log-rank χ^(2)=57.908,P<0.001).Conclusion:FPR is an independent prognostic factor and can predict the survival status of non-small cell lung cancer patients.

关 键 词：非小细胞肺癌 纤维蛋白原 前白蛋白 纤维蛋白原/前白蛋白比值 

分 类 号：R734.2[医药卫生—肿瘤]