乳腺化生性癌临床病理特征及预后影响因素分析  

The ananlysis of clinicopathological features and prognostic factors of metaplastic breast cancer

作　　者：钟镇铧 姜文强 范凤凤[1] 张静[1] 符颉 邹双吉 唐鲁兵[1] 李占文[1] Zhong Zhenhua

机构地区：[1]宁波市妇女儿童医院,315000

出　　处：《浙江临床医学》2022年第9期1279-1281,共3页Zhejiang Clinical Medical Journal

基　　金：宁波市自然科学基金资助项目(2018A610324);宁波市医学重点学科(2022-F27)。

摘　　要：目的分析乳腺化生性癌(MBC)的临床和病理学特征,探讨其预后及影响预后的因素.方法回顾性分析2006年至2020年38例MBC患者的临床及病理资料,采用Kaplan-Meier法进行生存分析,log-rank检验比较无病生存期(DFS)和总生存期(OS),Cox回归模型分析确定与DFS和OS相关的预后因素.结果患者中位年龄56岁.38例患者中,35例为三阴性乳腺癌(TNBC);13例有淋巴转移.34例接受化疗,26例接受放疗.随访(52.0±13.6)个月,14例患者出现复发或转移,9例患者出现死亡,1例患者失访.肿瘤大小、淋巴结是否转移、是否放疗和是否化疗是影响患者预后的重要因素,多因素分析发现化疗和放疗是独立预后影响因素.结论MBC是一种罕见而且预后较差的乳腺癌,化疗和放疗可以改善MBC患者的预后.Objective To analyze the clinicopathologca characteistis of metaplastic breast cancer,and to investigate the prognosis of metaplastie breast cancer and the factors afcting the prognosis Methods A total of 38 cases who diagnosed with metaplastic breast berween the years 2006 and 2020 were retrospectively analyzed.Kaplan-Meier curves were used to compare DFS and OS.The Cox regression model were used to analyze the prognostic factors related to DFS and OS.Results The median age of the patients was 56 years old.35 cases in a scries of 38 patients were triple-negative breast cancer(TNBC),13 cases had lymph node metastasis.34 cases received chemotherapy and 26 caes rceived rndiotherapy.During the fllw up(52.0土13.6)months,14 patients had recurrence or metastasis,9 patients died,and I patient was lost to follow-up.Tumor size,lymph node,radiotherapy and chemotherapy were important factors afcing the prognosis of patients.Multivariate analysis found that chemotherapy and nadiotherapy were independent prognostic factors.Conclusion Metaplastic breast cancer is a rare subtype of breast cancer.Chemotherapy and radiotherapy can improve the prognosis of patients with metaplastic breast cancer.

关 键 词：乳腺化生性癌 三阴性乳腺癌 预后 化疗 放疗 

分 类 号：R737.9[医药卫生—肿瘤]