单孔胸腔镜肺癌根治术对肺癌患者血清炎症因子水平和免疫功能指标的影响  

Effects of Single Hole Thoracoscopic Radical Resection of Lung Cancer on Serum Inflammatory Factors and Immune Function in Patients with Lung Cancer

作　　者：黄志毅[1] 吕昊 Huang Zhiyi;Lyu Hao(Fengcheng people's Hospital,Yichun Jiangxi 331100,China)

机构地区：[1]丰城市人民医院,江西宜春331100

出　　处：《医疗装备》2022年第22期76-79,共4页Medical Equipment

摘　　要：目的分析单孔胸腔镜肺癌根治术对肺癌患者血清炎症因子水平和免疫功能指标的影响。方法选取2019年1月至2020年1月丰城市人民医院收治的50例肺癌患者为研究对象,随机分为对照组和试验组,各25例。对照组实施传统三孔胸腔镜肺癌根治术,试验组实施单孔胸腔镜肺癌根治术,比较两组的手术相关指标、血清炎症因子水平及免疫功能指标水平。结果两组手术时间、术中出血量比较,差异无统计学意义(P>0.05);试验组术后胸腔引流管留置时间短于对照组,术后3 d视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05)。术后6 h,试验组C-反应蛋白(CRP)、去甲肾上腺素(NE)、肿瘤坏死因子-α(TNF-α)、血清降钙素原(PCT)水平均低于对照组,差异有统计学意义(P<0.05);试验组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标均高于对照组,差异有统计学意义(P<0.05)。结论单孔胸腔镜肺癌根治术可有效缩短术后胸腔引流管留置时间,减轻疼痛程度,降低血清炎症因子水平,改善机体免疫功能。Objective To analyze the effect of single-chamber thoracoscopic radical resection of lung cancer on serum inflammatory factors and immune function indexes in patients with lung cancer.Methods A total of 50 lung cancer patients admitted to Fengcheng People's Hospital from January 2019 to January 2020 were selected as the research objects.They were randomly divided into control group and observation group,with 25 cases in each group.The control group underwent traditional three-port thoracoscopic surgery,and the observation group underwent single-port thoracoscopic radical resection of lung cancer.The serum inflammatory factors and immune function indexes were compared between the two groups.Results There was no significant difference in operation time and intraoperative blood loss between the two groups(P>0.05).The postoperative chest tube indwelling time and VAS score in the observation group were lower than those in the control group(P<0.05).After treatment,C-reactive protein(CRP),norepinephrine(NE)and tumor necrosis factor in the test group-α(TNF-α)、Serum procalcitonin(PCT)levels were lower than those in the control group,the difference was statistically significant(P<0.05),and the indexes of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the test group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion The implementation of single-port thoracotomy for lung cancer can effectively reduce the level of serum inflammatory factors,reduce pain,and improve immune function,which can be promoted.

关 键 词：肺癌 单孔胸腔镜肺癌根治术 传统三孔法胸腔镜手术 血清炎症因子水平 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]