保健食品中非法添加新型卡巴地那非类似物的结构鉴定  

Structure Identification of a New Carbodenafil Related Compound Illegally Added to a Dietary Supplement

作　　者：夏佳 黄朝辉 席时东 Xia Jia;Huang Zhaohui;Xi Shidong(Ningbo Institute for Drug Control,Zhejiang Ningbo 315048,China)

机构地区：[1]宁波市药品检验所,浙江宁波315048

出　　处：《中国药师》2022年第10期1833-1836,共4页China Pharmacist

基　　金：国家市场监督管理局总局科技计划项目(编号:2019MK079)。

摘　　要：目的:鉴定保健食品中非法添加的一种新型卡巴地那非类似物的结构。方法:采用高效液相色谱-二极管阵列检测器联用(HPLC-DAD)筛查补肾壮阳类保健食品的非法添加,发现保健食品中添加了一种卡巴地那非类似物。经过制备液相提纯后,得到目标化合物,用超高效液相色谱-二级质谱联用(UPLC-MS/MS)获得相对分子质量和结构碎片。结合核磁共振氢谱和碳谱及相关文献数据,鉴定出该化合物的结构。结果:在保健食品中发现添加了一种新型卡巴地那非类似物羟基卡巴地那非。结论:该化合物不在现行食品中那非类物质的测定标准的90种目标化合物范围内,有必要对该化合物加以研究。Objective:To identify a new carbodenafil related compound illegally adulterated in a dietary supplement.Methods:A new carbodenafil related compound was detected in a routine screening for the compounds adulterated in a dietary supplement by HPLC-DAD.The target compound was isolated by preparative high performance liquid chromotography.Its molecular weight and structural fragments were obtained by HPLC-MS/MS.~1H-NMR spectrum and ^(13)C-NMR spectrum were obtained by nuclear magnetic resonance.Its structure was identified by analysis of all the data and related literature.Results:A new carbodenafil related compound named hydrocarbodenafil was detected in the dietary supplement.Conclusion:The compound is not in the current inspection standard list including 90 target compounds,and it is necessary to study this compound further.

关 键 词：保健食品 卡巴地那非类似物 羟基卡巴地那非 结构鉴定 

分 类 号：TQ460.72[医药卫生—药物分析学]