多发性骨髓瘤患者血清微小RNA-424、可溶性晚期糖基化终末产物受体、c-kit受体蛋白检测及临床意义  

Detection and clinical significance of serum miR-424,sRAGE and CD117 in patients with multiple myeloma

作　　者：杜娟英 薛海鲸 DU Juanying;XUE Haijing(Department of Laboratory Medicine,Baoji Central Hospital,Baoji 721008,China)

机构地区：[1]宝鸡市中心医院检验科,陕西宝鸡721008

出　　处：《陕西医学杂志》2022年第12期1585-1588,1592,共5页Shaanxi Medical Journal

基　　金：陕西省卫生健康科研基金资助项目(2021D008)。

摘　　要：目的:探讨多发性骨髓瘤患者血清微小RNA-424(miR-424)、可溶性晚期糖基化终末产物受体(sRAGE)、c-kit受体蛋白(CD117)检测及临床意义。方法:选择多发性骨髓瘤患者125例为观察组,另选一般资料与观察组相匹配的体检健康者125例为对照组,比较两组血清miR-424、sRAGE、CD117水平。观察不同临床分期及免疫分型多发性骨髓瘤患者血清miR-424、sRAGE、CD117水平的差异性。根据观察组患者是否合并肾损伤,分为肾损伤组和非肾损伤组,比较两组血清miR-424、sRAGE、CD117水平,并采用多因素Logistic回归分析血清miR-424、sRAGE、CD117与患者发生肾损伤的关系。结果:观察组血清miR-424、CD117水平高于对照组,sRAGE水平低于对照组(均P<0.05)。Ⅲ期患者血清miR-424、CD117水平均高于Ⅰ期和Ⅱ期患者,sRAGE水平低于Ⅰ期和Ⅱ期患者(均P<0.05)。IgG型患者血清miR-424和CD117水平高于IgA型、轻链型和非分泌型患者,sRAGE水平低于IgA型、轻链型和非分泌型患者(均P<0.05)。肾损伤组血清miR-424、sRAGE、CD117水平高于非肾损伤组(均P<0.05)。经多因素Logistic回归分析,血清miR-424、sRAGE、CD117是多发性骨髓瘤患者发生肾损伤的独立预测因素(均P<0.05)。结论:多发性骨髓瘤患者血清miR-424、CD117水平异常升高,sRAGE水平异常降低,三者与临床分期、免疫分型及肾损伤密切相关。Objective:To investigate the detection and clinical significance of serum microRNA-424(miR-424),soluble receptoRfoRadvanced glycation end products(sRAGE)and c-kit receptoRprotein(CD117)in patients with multiple myeloma and theiRclinical significance.Methods:A total of 125 patients with multiple myeloma were selected as the observation group,and 125 healthy subjects with general information matching with the observation group were selected as the control group.The levels of serum miR-424,sRAGE and CD117 were compared between the two groups.The differences of serum miR-424,sRAGE and CD117 levels in patients with multiple myeloma of different clinical stages and immunophenotypes were observed.The patients in the observation group were divided into kidney injury group and non-kidney injury group according to whetheRthe patients were complicated with kidney injury,and the levels of serum miR-424,sRAGE and CD117 in the two groups were compared,and the relationship between serum miR-424,sRAGE,CD117 and kidney injury was analyzed by multivariate Logistic regression.Results:The levels of serum miR-424 and CD117 in the observation group were higheRthan those in the control group,while the level of sRAGE was loweRthan that in the control group(all P<0.05).The serum levels of miR-424 and CD117 in stageⅢpatients were higheRthan those in stageⅠandⅡpatients,and sRAGE levels were loweRthan those in stageⅠandⅡpatients(all P<0.05).Serum miR-424 and CD117 levels were higheRin patients with IgG type than those in patients with IgA type,light chain type and non-secretory type,and sRAGE levels were loweRthan those in patients with IgA type,light chain type and non-secretory(all P<0.05).The levels of serum miR-424,sRAGE and CD117 in renal injury group were higheRthan those in non-renal injury group(all P<0.05).Multivariate Logistic regression analysis showed that serum miR-424,sRAGE and CD117 were independent predictors of kidney injury in patients with multiple myeloma(all P<0.05).Conclusion:Serum levels of miR-424 and CD117

关 键 词：多发性骨髓瘤 微小RNA-424 可溶性晚期糖基化终末产物受体 c-kit受体蛋白 临床分期 免疫分型 肾损伤 

分 类 号：R733.3[医药卫生—肿瘤]