圆柱瘤蛋白、白细胞介素-6、白细胞介素-8在结直肠癌及癌前病变中的表达差异及其与患者临床病理特征的关系  

Expression differences of cylindroma protein,IL-6 and IL-8 in colorectal cancer and precancerous lesions and theiRcorrelation with clinicopathological characteristics of patients

作　　者：朱绍华 何创业 赵芯 ZHU Shaohua;HE Chuangye;ZHAO Xin(Department of Gastroenterology,Xijing Hospital,AiRForce Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院消化内科,陕西西安710032

出　　处：《陕西医学杂志》2022年第12期1602-1606,共5页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(S2020-YF-YBSF-1186)。

摘　　要：目的:探究结直肠癌(CRC)及癌前病变患者组织标本中圆柱瘤蛋白(CYLD)、白细胞介素-6(IL-6)及IL-8的表达状况及其与患者临床病理特征的关系。方法:选取CRC患者70例、低级别上皮内瘤变(LGIN)患者35例和高级别上皮内瘤变(HGIN)患者35例,分别纳入CRC组、LGIN组和HGIN组,同时选取体检健康者70例纳入正常组(N组)。比较各组CYLD、IL-6、IL-8表达情况,分析CYLD、IL-6、IL-8与CRC患者临床病理特征的相关性以及CYLD与IL-6、IL-8表达的相关性。结果:四组CYLD、IL-6、IL-8阳性表达率比较,差异有统计学意义(均P<0.05)。CYLD、IL-6、IL-8表达在CRC患者性别、年龄及肿瘤位置方面比较差异无统计学意义(均P>0.05),在临床分期、肿瘤浸润深度、淋巴结转移等方面比较差异有统计学意义(均P<0.05)。Spearman相关性分析结果显示,CRC患者CYLD与IL-6、IL-8表达呈现负相关(R=-0.765、-0.289,均P<0.05)。结论:随着结直肠病变程度的加深,CYLD的表达呈现下调趋势,IL-6、IL-8的表达均呈上调趋势;同时在CRC患者组织标本中,CYLD、IL-6、IL-8的表达均与临床分期、肿瘤浸润深度及淋巴结转移存在显著关联,且CYLD的表达受到抑制可能会上调IL-6、IL-8的表达,从而加速CRC的发展。Objective:To investigate the expression of cylindroma protein(CYLD),IL-6 and IL-8 in colorectal canceR(CRC)and precancerous lesions and theiRcorrelation with clinicopathological characteristics of patients.Methods:Seventy patients with CRC,thirty-five patients with low-grade intraepithelial neoplasia(LGIN)and thirty-five patients with high-grade intraepithelial neoplasia(HGIN)were selected into CRC group,LGIN group and HGIN group respectively,and seventy healthy subjects were selected into normal group(group N).The expression of CYLD,IL-6 and IL-8 in each group was compared,and the correlation between CYLD,IL-6,IL-8 and clinicopathological characteristics of CRC patients and between CYLD and IL-6,IL-8 expression was analyzed.Results:The positive expression rates of CYLD,IL-6 and IL-8 in the fouRgroups were significantly different(all P<0.05).There was no significant difference in the expression of CYLD,IL-6 and IL-8 in sex,age and tumoRlocation of CRC patients(all P>0.05),but there was significant difference in clinical stage,tumoRinvasion depth and lymph node metastasis(all P<0.05).Spearman correlation analysis showed that CYLD was negatively correlated with IL-6 and IL-8 expression in CRC patients(R=-0.765,-0.289,all P<0.05).Conclusion:With the deepening of colorectal lesions,the expression of CYLD showed a downward trend,and the expressions of IL-6 and IL-8 showed an upward trend.At the same time,in tissue specimens of colorectal canceRpatients,the expressions of CYLD,IL-6 and IL-8 were significantly correlated with clinical stage,tumoRinvasion depth and lymph node metastasis.In addition,the inhibition of CYLD expression may increase the expression of IL-6 and IL-8,thereby accelerating the development of colorectal cancer.

关 键 词：结直肠癌 圆柱瘤蛋白 白细胞介素-6 白细胞介素-8 癌前病变 临床病理特征 

分 类 号：R735.34[医药卫生—肿瘤]