针刺治疗慢性严重功能性便秘患者排便次数最小临床意义变化值研究  

Minimal clinically important difference of the frequency of bowel movement for patients with chronic severe functional constipation treated with acupuncture

作　　者：艾艳珂[1] 刘志顺[2] 刘保延[3] 张艳宏 李杨 孙海舒[6] 曹雪 刘佳[1] 杨卓欣[7] 于海波[7] 黄杏贤[7] 何丽云[1] AI Yan-ke;LIU Zhi-shun;LIU Bao-yan;ZHANG Yan-hong;LI Yang;SUN Hai-shu;CAO Xue;LIU Jia;YANG Zhuo-xin;YU Hai-bo;HUANG Xing-xian;HE Li-yun(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Department of Acupuncture and Moxibustion,Guang'anmen Hospital,China Academy of Chinese Medical Sciences;TCM Data Center,China Academy of Chinese Medical Sciences;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences;Department of Acupuncture and Moxibustion,Beijing Fengtai You'anmen Hospital;Institute of Chinese Medicine Information,China Academy of Chinese Medical Sciences;Department of Acupuncture and Moxibustion,Shenzhen TCM Hospital)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院广安门医院针灸科 [3]中国中医科学院中医药数据中心 [4]中国中医科学院针灸研究所 [5]北京丰台右安门医院针灸科 [6]中国中医科学院中医药信息研究所 [7]深圳市中医院针灸科

出　　处：《中国针灸》2022年第11期1247-1250,共4页Chinese Acupuncture & Moxibustion

基　　金：“三名工程”中国中医科学院刘保延首席研究员中医针灸临床评价方法创新团队项目:SZSM201612001;中国中医科学院育苗基金培育专项项目:ZZ11-112;中国中医科学院中医临床基础医学研究所自由探索项目:Z0741。

摘　　要：目的:评估针刺治疗慢性严重功能性便秘患者排便次数的最小临床意义变化值(MCID),为临床决策提供依据。方法:纳入既往两项随机对照试验中813例接受针刺治疗的慢性严重功能性便秘患者,通过校标法[以便秘患者生活质量量表(PAC-QOL)第28条“对以往治疗满意度”为校标]和分布法,对患者平均每周完全自主排便(CSBM)次数和自主排便(SBM)次数的MCID进行统计分析。结果:针刺治疗慢性严重功能性便秘患者平均每周CSBM和SBM次数的MCID分别为1.3次和1.6次(校标法)。结论:慢性严重功能性便秘患者在治疗后平均每周CSBM较治疗前增加≥1.3次、SBM增加≥1.6次具有临床意义。Objective To estimate the minimal clinically important difference(MCID)of the frequency of bowel movement for the patients with chronic severe functional constipation treated with acupuncture so as to provide the evidence for the clinical decision.Methods In this study,813 patients with chronic severe functional constipation treated with acupuncture in two previous randomized controlled trials were included.Through the anchor-based method(anchored by the item 28"satisfaction with previous treatment"of the patient assessment of constipation-quality of life[PAC-QOL])and the distribution-based method,the MCID of the weekly frequency of complete spontaneous bowel movement(CSBM)and spontaneous bowel movement(SBM)was analyzed statistically in the patients.Results The MCID of the mean weekly frequency of CSBM and SBM was 1.3 times and 1.6 times in patients with chronic severe functional constipation treated with acupuncture,respectively.Conclusion The mean increase of the weekly CSMB is≥1.3 times and that of SBM is≥1.6 times after treatment when compared with the baseline respectively,suggesting the clinical significance.

关 键 词：慢性严重功能性便秘 针刺 完全自主排便次数 自主排便次数 最小临床意义变化值 

分 类 号：R246.1[医药卫生—针灸推拿学]