甲状腺乳头状癌术后血清缺氧诱导因子2α和可溶性白介素-2受体的表达与预后的关系研究  

The Relationship between the Expression of Serum HIF-2α,SIL-2R and Prognosis in Patients with Papillary Thy⁃roid Carcinoma after Surgery

作　　者：魏坦 WEI Tan(Zhongkai High-tech Zone People’s Hospital,Huizhou,Guangdong,516000,China)

机构地区：[1]惠州仲恺高新区人民医院,广东惠州516000

出　　处：《黑龙江医学》2022年第21期2614-2617,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨甲状腺乳头状癌术后血清缺氧诱导因子2α(HIF-2α)、可溶性白介素-2受体(SIL-2R)的表达与预后的关系。方法:选取惠州仲恺高新区人民医院2018年1月―2020年10月收治的60例甲状腺乳头状癌患者及60例术后病理证实的良性甲状腺结节患者作为研究对象,分别为乳头状癌组和良性组。比较两组患者血清HIF-2α、SIL-2R阳性率,比较乳头状癌组血清HIF-2α和SIL-2R水平与临床病理特征的关系,比较乳头状癌组预后复发情况与血清HIF-2α、SIL-2R阳性表达的关系。结果:乳头状癌组血清HIF-2α、SIL-2R水平阳性率高于良性组,差异有统计学意义(χ^(2)=39.624、30.857,P<0.05)。乳头状癌分化程度低、复发患者血清HIF-2α阳性表达率高于分化程度高、无复发者,差异有统计学意义(χ^(2)=4.774、9.966,P<0.05)。乳头状癌分化程度低、复发患者血清SIL-2R阳性表达率高于分化程度高、无复发者,差异有统计学意义(χ^(2)=4.426、13.806,P<0.05)。乳头状癌组患者预后复发与血清HIF-2α、SIL-2R水平均呈正相关(P<0.05)。logistic多因素分析结果显示,甲状腺乳头状癌组织中血清HIF-2α、SIL-2R阳性表达是影响分化程度和复发情况的独立因素(P<0.05)。结论:血清HIF-2α、SIL-2R在甲状腺乳头状癌中的过度表达与分化程度和复发情况有关,术后严密监测血清HIF-2α、SIL-2R表达情况有利于治疗方案的制定。Objective:To investigate the relationship between the expressions of serum hypoxia-inducible factor 2α(HIF-2α)and soluble interleukin-2 receptor(SIL-2R)and prognosis after papillary thyroid carcinoma surgery.Methods:A total of 60 patients with papillary thyroid cancer and 60 patients with postoperative pathologically confirmed benign thyroid nodules who were admitted to the hospital from January 2018 to October 2020 were selected as the research objects,and divided into a papillary cancer group and a benign group.The positive rates of serum HIF-2αand SIL-2R in the two groups were compared,and the relationship between the levels of serum HIF-2αand SIL-2R in the papillary carcinoma group and the clinicopathological characteristics were compared.The relationship between the prognosis and recurrence of papillary carcinoma group and the positive expressions of serum HIF-2αand SIL-2R were compared.Results:The positive rates of serum HIF-2αand SIL-2R levels in the papillary carcinoma group were higher than those in the benign group,and the difference was statistically significant(χ^(2)=39.624,30.857,P<0.05).The positive expression rate of serum HIF-2αin patients with low degree of differentiation and recurrence of papillary carcinoma was higher than that in patients with high degree of differentiation and no recurrence,and the difference was statistically significant(χ^(2)=4.774,9.966,P<0.05).The positive expression rate of serum SIL-2R in patients with low differentiation degree and recurrence of papillary carcinoma was higher than that in patients with high differentiation degree and no recurrence,and the difference was statistically significant(χ^(2)=4.426,13.806,P<0.05).The prognosis and recurrence of papillary carcinoma group were positively correlated with serum HIF-2αand SIL-2R levels(P<0.05).The results of logistic multivariate analysis showed that the positive expressions of serum HIF-2αand SIL-2R in papillary thyroid carcinoma were independent factors affecting the degree of differentiation and rec

关 键 词：甲状腺乳头状癌 缺氧诱导因子2α 可溶性白介素-2受体 病理特征 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]