Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates  

作　　者：Yi Wu Yanqiong Shen Namei Wu Xinghai Zhang Shaohong Chen Chang Yang Junhui Zhou Yan Wu Da Chen Li Wang Chao Wang Huajun Zhang Ninuo Xia Sandra Chiu Yucai Wang 

机构地区：[1]Department of Radiology,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China [2]School of Basic Medical Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China [3]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety MegaScience,Chinese Academy of Sciences,Wuhan,Hubei,China [4]University of Chinese Academy of Sciences,Beijing,China [5]MOE Key Laboratory for Cellular Dynamics,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China [6]RNAlfa Biotech,Hefei,Anhui,China.

出　　处：《Cell Research》2022年第10期949-952,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program of China(2020YFA0710700);the National Natural Science Foundation of China(52025036,51961145109);the Fundamental Research Fund for the Central Universities(WK9100000014,WK2480000006,and WK9110000061);the project of collaborative innovation for colleges of Anhui province(GXXT-2021-070).

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 400 million people globally,resulting in millions of deaths.1 As the virus evolves,a new variant,designated as“Omicron”by the World Health Organization(SARS-CoV-2 variant B.1.1.529),has led to a massive resurgence of COVID-19 cases in many regions.2 The Omicron variant is highly contagious,with a significant transmission advantage compared to prior variants.Currently,Omicron represents~95%of the new infections in the US,Europe,Brazil,South Africa,and elsewhere.3–5 The remarkable transmissibility of Omicron is likely attributable to its highly mutated spike(S)gene(more than 30 mutations),which promotes S protein binding to the cellular receptor angiotensin-converting enzyme 2(ACE2)and allows it to escape from both humoral and cellular immunity elicited by prior infection or vaccination.6,7 Several studies show that the Omicron variant significantly affects the protection conferred by previous vaccinations including mRNA vaccines of mRNA-1273(Moderna)and BNT162b2(Pfizer BioNTech)。

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分 类 号：Q2[生物学—细胞生物学]