转化生长因子-β1在胃癌组织中的表达及对临床病理特征和预后的影响  

Expression of transforming growth factor-β1 in gastric cancer and its influence on clinicopathological features and prognosis

作　　者：邱进 马廷午 李旭忠 QIU Jin;MA Ting-wu;LI Xu-zhong(The Second Department of General Surgery,Puyang Oilfield General Hospital Affiliated to Xinxiang Medical College,Puyang457001,China)

机构地区：[1]新乡医学院附属濮阳市油田总医院普外二科,河南濮阳457001

出　　处：《中国现代普通外科进展》2022年第11期882-885,889,共5页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:检测转化生长因子-β1(TGF-β1)在胃癌组织中的表达情况,并分析其对胃癌临床病理特征和预后的影响。方法:收集2016年1月—2018年1月接受胃癌手术治疗的患者176例,免疫组织化学检测胃癌组织中TGF-β1的表达情况,根据免疫组织化学评分将患者分为TGF-β1高表达组(n=89),TGF-β1低表达组(n=87)。比较两组间的临床病理特征,采用Kaplan-Meier法绘制生存曲线,Log-rank检测两组间的总生存率和疾病无进展生存率,单因素和多因素Cox回归分析影响胃癌生存的危险因素。结果:胃癌组织中TGF-β1阳性表达率77.8%(137/176),高于癌旁组织的9.7%(17/176,χ^(2)=166.234,P<0.001)。胃癌组织中TGF-β1高表达率50.6%(89/176),高于癌旁组织(0/176,χ^(2)=119.118,P<0.001)。TGF-β1的表达与肿瘤大小、分化程度、TNM分期、淋巴结转移和浸润深度有关(P<0.05)。TGF-β1高表达组术后3年的总生存率为67.4%(60/89),低于TGF-β1低表达组的92.0%(80/87,χ^(2)=16.051,P<0.001)。TGF-β1高表达组术后3年的疾病无进展生存率为61.8%(55/89),低于TGF-β1低表达组86.2%(75/87,χ^(2)=13.425,P<0.001)。经过Cox单因素和多因素回归分析显示,肿瘤分化程度[HR(95%CI):1.658(1.085~3.658),P<0.001]、TNM分期[HR(95%CI):1.265(1.058~1.965),P=0.010]、浸润深度[HR(95%CI):1.351(1.095~4.325),P<0.001]和TGF-β1表达[HR(95%CI):2.341(1.326~5.201),P<0.001]为影响胃癌患者术后生存的独立危险因素。结论:TGF-β1在胃癌组织中表达率高,可能参与肿瘤的增殖和侵袭,影响患者的总生存率,是患者预后不良的独立危险因素。Objective:To detect the expression of transforming growth factor-β1(TGF-β1)in gastric cancer tissues and analyze its influence on the clinicopathological features of gastric cancer and prognosis of patients.Methods:A total of 176 patients who underwent gastric cancer surgery in our hospital from January 2016 to January 2018 were collected.Immunohistochemistry was used to detect the expression of TGF-β1 in gastric cancer tissues,and the patients were classified as high TGF-β1 group(n=89)and low TGF-β1 group(n=87)according to the immunohistochemical score.Chi-square test was used to compare the clinicopathological characteristics between the two groups.The Kaplan-Meier method was used to draw the survival curve.The Log-rank was used to detect the overall survival rate and disease-free survival rate between the two groups.Univariate and multivariate Cox regression analysis of risk factors affecting survival of gastric cancer.Results:The positive expression rate of TGF-β1 in gastric cancer tissue was 77.8%(137/176),higher than adjacent tissues of gastric cancer 9.7%(17/176,χ^(2)=166.234,P<0.001).The high expression rate of TGF-β1 in gastric cancer tissue was 50.6%(89/176),which was higher than in adjacent tissues of gastric cancer,χ^(2)=119.118,P<0.001.The expression of TGF-β1 in gastric cancer tissue was related to the patient’s tumor size,tumor differentiation,TNM stage,lymph node metastasis and depth of invasion(P<0.05).The 3-year overall survival rate of the TGF-β1 high expression group was 67.4%(60/89),which was lower than the TGF-β1 low expression group of 92.0%(80/87),χ^(2)=16.051,P<0.001.The 3-year progression-free survival rate of the TGF-β1 high expression group was 61.8%(55/89),which was lower than that of the TGF-β1 low expression group of 86.2%(75/87),χ^(2)=13.425,P<0.001.Cox single factor and multivariate regression analysis showed that the degree of tumor differentiation[HR(95%CI)=1.658(1.085~3.658),P<0.001],TNM stage[HR(95%CI)=1.265(1.058~1.965),P=0.010],depth of invasion[HR(95%CI)=1

关 键 词：胃肿瘤 转化生长因子-1β 病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]