CT引导下氩氦刀冷冻消融联合放射治疗对肺癌患者疾病控制的影响  

Effect of CT-guided Argon Helium Cryoablation Combined with Radiotherapy on Disease Control in Patients with Lung Cancer

作　　者：胡涛[1] 侯明杰[1] 王发权 HU Tao;HOU Ming-jie;WANG Fa-quan(Jiaozuo People's Hospital,Henan Jiaozuo 454002)

机构地区：[1]焦作市人民医院,河南焦作454002

出　　处：《深圳中西医结合杂志》2022年第15期82-85,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:研究计算机断层扫描(CT)引导下氩氦刀冷冻消融联合放射治疗对肺癌患者疾病控制的影响。方法:选取焦作市人民医院2017年2月至2019年12月收治的经病理学确诊的120例肺癌患者,根据随机数字表法将患者分为对照组和观察组,各60例,对照组采用常规放射治疗,观察组采用CT引导下氩氦刀冷冻消融联合放射治疗,比较两组肿瘤控制率、毒副反应、治疗前后免疫相关指标水平及随访2年后生存质量情况。结果:观察组治疗后的肿瘤控制率为75.00%,明显高于对照组的46.67%,差异具有统计学意义(P<0.05);与治疗前相比,两组患者治疗后CD4^(+)、CD4^(+)/CD8^(+)水平均升高,CD8^(+)较治疗前降低,观察组的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)均优于对照组,差异均具有统计学意义(P<0.05),观察组患者随访期间生存质量的稳定率及改善率分别为76.67%、48.33%,明显高于对照组的63.33%、21.67%,差异具有统计学意义(P<0.05);观察组患者治疗期间的毒副反应发生率为11.67%,明显低于对照组28.33%,差异具有统计学意义(P<0.05)。结论:采用CT引导下氩氦刀冷冻消融联合放射治疗治疗肺癌患者,相较于单纯放射治疗可改善临床疗效,提高患者生存质量,减少毒副反应发生率,提高患者免疫功能。Objective To investigate the effect of argon-helium cryoablation combined with radiotherapy guided by computed tomography(CT)on disease control in patients with lung cancer.Methods A total of 120 patients with pathologically confirmed lung cancer admitted to Jiaozuo People's Hospital from February 2017 to December 2019 were selected and divided into a control group and an observation group according to the random number method,with 60 cases in each group.The control group was treated with conventional radiotherapy,while the observation group was treated with CT-guided argon-helium cryoablation combined with radiotherapy.The tumor control rate,toxic and side effects,immune-related indicators before and after treatment,and quality of life after two years of follow-up were compared between the two groups.Results The tumor control rate of the observation group after treatment was 75.00%,which was significantly higher than 46.67%of the control group,and the difference was statistically significant(P<0.05).Compared with before treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased after treatment,and CD8^(+)was decreased compared with before treatment.The levels of CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).The stability rate and improvement rate of quality of life in the observation group during follow-up were 76.67%and 48.33%,which were significantly higher than those in the control group(63.33%and 21.67%,P<0.05).The incidence of side effects in the observation group was 11.67%,which was significantly lower than 28.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion CT guided argon helium cryoablation combined with radiotherapy for lung cancer patients can improve the clinical efficacy,improve the quality of life,reduce the incidence of side effects,and improve the immune function of patients.

关 键 词：肺癌 氩氦刀冷冻消融 计算机断层扫描引导 放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]