慢性萎缩性胃炎诊疗和羔羊胃提取物维B12临床应用专家指导意见  

The specialist instruction for diagnosis and treatment of chronic atrophic gastritis and clinical application of Lamb′s tripe extract and vitamin B12 capsule

作　　者：时永全 陈敏 王学红 郑勇[3] 曲波[4] 张晓岚[5] 杨仕明 吴开春 Shi Yongquan;Chen Min;Wang Xuehong;Zheng Yong;Qu Bo;Zhang Xiaolan;Yang Shiming;Wu Kaichun(National Clinical Research Center for Digestive Diseases,State Key Laboratory of Cancer Biology,Department of Gastroenterology,First Affiliated Hospital,Air Force Medical University,Xi′an 710032,China;Department of Gastroenterology,the Hospital Affiliated to Qinghai University,Xining 810000,China;Department of Gastroenterology,First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi 832008,China;Department of Gastroenterology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Gastroenterology,Second Affiliated Hospital,Land Force Medical University,Chongqing 400037,China)

机构地区：[1]空军军医大学第一附属医院消化内科肿瘤生物学国家重点实验室国家消化系统疾病临床医学研究中心,西安710032 [2]青海大学附属医院消化内科,西宁810000 [3]石河子大学医学院第一附属医院消化内科,石河子832008 [4]哈尔滨医科大学附属第二医院消化内科,哈尔滨150001 [5]河北医科大学第二医院消化内科,石家庄050000 [6]陆军军医大学第二附属医院消化内科,重庆400037

出　　处：《中华消化杂志》2022年第9期577-584,共8页Chinese Journal of Digestion

摘　　要：慢性萎缩性胃炎(CAG),以及在此基础上发生的胃黏膜肠上皮化生(GIM)使胃癌发生风险显著升高,阻断胃黏膜萎缩和GIM的发展对于降低胃癌发病率具有重要意义。既往研究认为,根除幽门螺杆菌可在一定程度上逆转胃黏膜萎缩。新近研究发现,GIM也可在一定程度上被逆转。临床研究表明,羔羊胃提取物维B12对GIM具有显著的逆转效应。本文就CAG诊疗和羔羊胃提取物维B12临床应用进行综述,并制定专家指导意见,以更好地指导CAG和GIM的逆转治疗。Chronic atrophic gastritis(CAG)and gastric intestinal metaplasia(GIM)significantly increase the risk of gastric cancer.Blocking the development of CAG and GIM would help to decrease the incidence of gastric cancer.It was revealed that eradication of Helicobacter pylori could reverse gastric mucosa atrophy.Recent studies reported that GIM could be reversed to a certain extent.Clinical studies demonstrated that Lamb′s tripe extract and vitamin B12 capsule exhibited significant reversal effects on GIM.The present study systemically reviewed the diagnosis and treatment of CAG and clinical application of Lamb′s tripe extract and vitamin B12 capsule,and established the specialist instruction that would guide the reversal treatment of CAG and GIM.

关 键 词：慢性萎缩性胃炎 肠上皮化生 羔羊胃提取物维B12 幽门螺杆菌 

分 类 号：R573.3[医药卫生—消化系统]