妊娠期外源性孕激素的使用对牙周炎的影响  

Effects of Exogenous Progestogen Use on Periodontitis During Pregnancy

作　　者：梁剑梅[1] 韦静[1] 周燕平[1] 蒋炳林[1] Liang Jian-mei;Wei Jing;Zhou Yan-ping;Jiang Bing-lin(Department of Stomatology,Liuzhou People's Hospital,Liuzhou 545000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]柳州市人民医院口腔科,广西柳州545000

出　　处：《中国社区医师》2022年第31期32-34,共3页Chinese Community Doctors

基　　金：广西壮族自治区卫生健康委(Z20190343)。

摘　　要：目的:探讨妊娠期使用外源性孕激素对牙周炎的影响。方法:选取2019年9月-2022年2月柳州市人民医院收治的120例孕妇为研究对象,根据怀孕方式分为观察组和对照组,各60例。观察组为进行体外授精-胚胎移植怀孕的孕妇,对照组为自然怀孕未使用外源性孕激素的孕妇。对比两组白细胞介素2(IL-2)水平、牙周相关指标及妊娠结局。结果:观察组血清IL-2水平、牙龈出血指数、探诊深度值高于对照组,临床附着丧失、探诊出血指数低于对照组,差异有统计学意义(P<0.05)。观察组分娩孕周小于对照组,新生儿体重轻于对照组,早产、低体重的不良妊娠发生率高于对照组,差异有统计学意义(P<0.05)。结论:体外授精-胚胎移植孕妇由于使用外源性孕激素剂量较多,罹患牙周炎的危险性大,妊娠不良结局的发生率增高,因此应加强孕妇特别是体外授精-胚胎移植孕妇孕期口腔卫生宣教。Objective:To investigate the effect of exogenous progesterone use during pregnancy on periodontitis.Methods:A total of 120 pregnant women who were treated in Liuzhou People's Hospital from September 2019 to February 2022 were selected as the study subjects.According to the pregnancy method,they were divided into observation group and control group,with 60 cases in each group.In the observation group,pregnant women were pregnant through in vitro fertilization and embryo transfer.In the control group,pregnant women were naturally pregnant without use of exogenous progestogen.Interleukin-2(IL-2)levels,periodontal related indexes,and pregnancy outcomes were compared between the two groups.Results:The serum IL-2 level,gingival bleeding index and probing depth value in the observation group were higher than those in the control group,while the clinical attachment loss and probing bleeding index in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The gestational age of delivery in the observation group was smaller than that in the control group,the neonatal weight in the observation group was lower than that in the control group,and the incidence of preterm birth and low birth weight in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).Conclusion:Due to the higher dose of exogenous progestogen used during pregnancy,the pregnant women by in vitro fertilization and embryo transfer are at a greater risk of periodontitis and the incidence of adverse pregnancy outcomes increased,therefore,it is necessary to strengthen the oral health education of pregnant women during pregnancy,especially those by in vitro fertilization-embryo transfer pregnant women.

关 键 词：牙周炎 外源性孕激素 体外授精-胚胎移植 自然怀孕 

分 类 号：R781.42[医药卫生—口腔医学]