裸花紫珠胶囊联合西药治疗肝硬化上消化道出血临床研究  

Clinical Study on Luohua Zizhu Capsules Combined with Western Medicine for Upper Gastrointestinal Hemorrhage Due to Cirrhosis

作　　者：潘小琴 肖辉 尹强龙 PAN Xiaoqin;XIAO Hui;YIN Qianglong

机构地区：[1]浙江新安国际医院急诊医学科,浙江嘉兴314001

出　　处：《新中医》2022年第19期101-104,共4页New Chinese Medicine

摘　　要：目的:观察裸花紫珠胶囊联合西药治疗肝硬化上消化道出血对患者血流动力学、肝功能及再出血率的影响。方法:选择86例肝硬化上消化道出血患者,按其治疗方式不同分为观察组和对照组。观察组45例使用裸花紫珠胶囊联合盐酸普萘洛尔片治疗,对照组41例单纯使用盐酸普萘洛尔片治疗,比较2组止血时间、住院时间、再出血率、不良反应发生情况及治疗前后门静脉血流量、脾静脉血流量、肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)]。结果:观察组止血时间、住院时间短于对照组(P<0.05),再出血率低于对照组(P<0.05)。与同组治疗前比较,治疗后2组门静脉、脾静脉血流量均减少(P<0.05);与对照组治疗后比较,观察组治疗后门静脉、脾静脉血流量均较少(P<0.05)。与同组治疗前比较,治疗后2组ALT、AST、TBil水平均降低(P<0.05);与对照组治疗后比较,观察组治疗后ALT、AST、TBil水平均较低(P<0.05)。观察组不良反应总发生率11.11%,低于对照组34.15%(P<0.05)。结论:裸花紫珠胶囊联合盐酸普萘洛尔片治疗肝硬化上消化道出血患者能够有效改善血流动力学、止血效果较好、肝功能恢复显著、不良反应发生率低。Objective:To observe the effect of Luohua Zizhu capsules combined with western medicine on hemodynamics, liver function and recurrent bleeding rates in patients with upper gastrointestinal hemorrhage due to cirrhosis. Methods: A total of 86 cases of patients with upper gastrointestinal hemorrhage due to cirrhosis were selected and divided into the observation group and the control group according to their different treatment methods, with 45 and 41 cases in each group respectively. The observation group was treated with Luohua Zizhu capsules combined with propranolol hydrochloride tablets,and the control group was simply treated with propranolol hydrochloride tablets. The hemostatic time,hospitalization time,recurrent bleeding rates,and incidence of adverse reactions in the two groups were compared. Before and after treatment,the blood flow in portal vein and splenic vein,and the liver function indexes including alanine aminotransferase(ALT), aspartate aminotransferase(AST) and total bilirubin(TBil) in the two groups were compared. Results:The hemostatic time,hospitalization time in the observation group were shorter than those in the control group(P<0.05),the recurrent bleeding rates were lower(P<0.05). After treatment, the blood flow in portal vein and splenic vein in the two groups was decreased when compared with that before treatment(P<0.05), and the blood flow in portal vein and splenic vein in the observation group was less than that in the control group(P<0.05). After treatment,the levels of ALT,AST and TBil in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of ALT, AST and TBil in the observation group were lower than those in the control group(P<0.05). The total incidence of adverse reactions was 11.11% in the observation group,lower than that of 34.15% in the control group(P<0.05). Conclusion:Luohua Zizhu capsules combined with western medicine for patients with upper gastrointestinal hemorrhage due to cirrhosis can effectively improve their hemodynamics

关 键 词：肝硬化 上消化道出血 裸花紫珠胶囊 盐酸普萘洛尔片 血流动力学 肝功能 再出血 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]