滋肾开郁安神汤治疗心肾不交证抑郁症临床研究  

Clinical Study on Zishen Kaiyu Anshen Tang for Depression with Syndrome of NonInteraction Between the Heart and Kidney

作　　者：谢小华 刘根芳 XIE Xiaohua;LIU Genfang

机构地区：[1]常山县人民医院中医科,浙江常山324200 [2]衢州市中医院中医科,浙江衢州324002

出　　处：《新中医》2022年第20期39-43,共5页New Chinese Medicine

摘　　要：目的:观察滋肾开郁安神汤联合盐酸氟西汀胶囊治疗抑郁症的临床效果。方法:选择102例心肾不交证抑郁症患者作回顾性分析,按照不同治疗方法分为对照组50例和观察组52例。对照组应用盐酸氟西汀胶囊治疗,观察组应用滋肾开郁安神汤治疗。2组疗程均为6周,观察比较2组治疗前后血清去甲肾上腺素(NE)、5-羟色胺(5-HT)水平;比较2组治疗前后汉密尔顿抑郁量表(HAMD-17)、症状自评量表(SCL-90)及中医证候积分;比较2组临床治疗效果及用药安全性。结果:观察组总有效率为92.31%,对照组为76.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清NE、5-HT水平比较,差异无统计学意义(P>0.05)。治疗后,2组NE、5-HT水平均较治疗前升高(P<0.05),且观察组NE、5-HT水平均高于对照组(P<0.05)。治疗前,2组HAMD-17、SCL-90评分及中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组HAMD-17、SCL-90、中医证候积分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。观察组不良反应发生率为1.92%,对照组为16.00%,2组比较,差异有统计学意义(P<0.05)。结论:滋肾开郁安神汤联合盐酸氟西汀胶囊治疗抑郁症疗效优于单用西药治疗,可更好地改善临床症状,调节血清NE、5-HT水平,且不良反应较少。Objective:To observe the clinical effect of Zishen Kaiyu Anshen tang combined with Fluoxetine Hydrochloride Capsules for depression.Methods:A total of 102 cases of patients with depression with syndrome of non-interaction between the heart and kidney were retrospectively analyzed and divided into the control group and the observation group according to different treatment methods,with 50 and 52 cases in each group respectively.The control group was given Fluoxetine Hydrochloride Capsules,and the observation group was treated with Zishen Kaiyu Anshen tang.The course of treatment in the two groups was six weeks.The levels of norepinephrine(NE)and 5-hydroxytryptamine(5-HT)in serum in the two groups were observed and compared before and after treatment;Hamilton Depression Rating Scale(HAMD-17),Symptom Checklist-90(SCL-90)and Chinese medicine syndrome scores were compared between the two groups before and after treatment;the clinical effects and medication safety in the two groups were compared.Results:The total effective rate was 92.31%in the observation group and76.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of NE and 5-HT in serum between the two groups(P>0.05).After treatment,levels of NE and 5-HT in the two groups were increased when compared with those before treatment(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of HAMD-17,SCL-90 and Chinese medicine syndrome between the two groups(P>0.05).After treatment,scores of HAMD-17,SCL-90 and Chinese medicine syndrome in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 1.92%in the observation group and 16.00%in the control group,the difference b

关 键 词：抑郁症 心肾不交证 滋肾开郁安神汤 盐酸氟西汀胶囊 汉密尔顿抑郁量表 症状自评量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]