白芍七物颗粒联合双歧杆菌三联活菌散对溃疡性结肠炎患者血清炎症因子及氧化应激指标的影响  

Effect of Baishao Qiwu Granules Combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Powder on Serum Inflammatory Factors and Oxidative Stress Indexes in Patients with Ulcerative Colitis

作　　者：潘渊[1] 张磊[1] 刘兆辉[1] 陈冬[1] 刘道成 徐小平[1] 何小平 PAN Yuan;ZHANG Lei;LIU Zhaohui;CHEN Dong;LIU Daocheng;XU Xiaoping

机构地区：[1]杭州市余杭区第一人民医院肛肠外科,浙江杭州311100 [2]不详

出　　处：《新中医》2022年第20期64-68,共5页New Chinese Medicine

基　　金：浙江省自然科学基金一般项目(LY19H030012)。

摘　　要：目的:观察白芍七物颗粒联合双歧杆菌三联活菌散对溃疡性结肠炎患者血清炎症因子及丙二醛(MDA)、超氧化物歧化酶(SOD)水平的影响。方法:选取溃疡性结肠炎患者94例,根据随机数字表法分为对照组和观察组各47例。对照组在常规治疗的基础上加用双歧杆菌三联活菌散口服,观察组在对照组的基础上加用白芍七物颗粒口服。疗程均为2个月,观察比较2组总体临床疗效,以及2组治疗前后症状评分、氧化应激指标(MDA、SOD)、血清炎症因子[C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平变化。结果:治疗后,观察组临床疗效优于对照组,经秩和检验,差异有统计学意义(P<0.05)。治疗前,2组MDA、SOD水平比较,差异无统计学意义(P>0.05);治疗后,2组SOD水平均较治疗前上升(P<0.05)、MDA水平均较治疗前降低(P<0.05),且观察组SOD水平高于对照组(P<0.05)、MDA水平低于对照组(P<0.05)。治疗前,2组CRP、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组CRP、IL-6、TNF-α水平均较治疗前降低(P<0.05),且观察组CRP、IL-6、TNF-α水平均低于对照组(P<0.05)。治疗前,2组腹痛、腹泻、黏液脓血便、里急后重等症状评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项症状评分均较治疗前降低(P<0.05),且观察组各项症状评分均低于对照组(P<0.05)。结论:在常规治疗的基础上,应用白芍七物颗粒联合双歧杆菌三联活菌散治疗溃疡性结肠炎,有助于改善体内MDA、SOD水平,降低血清炎症因子水平,缓解相关临床症状。Objective:To investigate the effect of the therapy of Baishao Qiwu granules combined with Live combined Bifidobacterium,Lactobacillus and Enterococcus powder on serum inflammatory factors,malondialdehyde(MDA)level and superoxide dismutase(SOD)level in patients with ulcerative colitis.Methods:A total of 94 patients with ulcerative colitis were selected and divided into the control group and the observation group according to random number table method,with 47 cases in each group.The control group was additionally treated with Live combined Bifidobacterium,Lactobacillus and Enterococcus powder orally based on the conventional treatment,and the observation group was additionally treated with Baishao Qiwu granules orally based on the treatment of the control group.The treatment course was two months.The overall clinical effects and symptom scores,oxidative stress indexes,including MDA and SOD,and serum inflammatory factors,including C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)before and after treatment in both groups were observed and compared.Results:After treatment,the clinical effect in the observation group was better than that in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference in the comparison of MDA and SOD levels between the two groups(P>0.05);after treatment,the SOD levels in both groups were increased and the MDA levels were decreased(P<0.05),and the SOD level in the observation group was higher than that in the control group and the MDA level was lower(P<0.05).Before treatment,there was no significant difference in the comparison of CRP,IL-6 and TNF-αlevels between the two groups(P>0.05);after treatment,the levels of CRP,IL-6 and TNF-αin the two groups were lower than those before treatment(P<0.05),and the levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the comparison of the symptom scores of abd

关 键 词：溃疡性结肠炎 白芍七物颗粒 双歧杆菌三联活菌散 炎症因子 氧化应激 

分 类 号：R574.6[医药卫生—消化系统]