回顾性分析放化疗在局部中晚期NPC中的作用  

Retrospective study of the role of chemoradiotherapy in the treatment of locoregionally moderate or advanced NPC

作　　者：王晓丽[1] 郝福荣[1] WANG Xiaoli;HAO Furong(Department of Radiation Oncology,Weifang People’s Hospital,Weifang 261041,China)

机构地区：[1]潍坊市人民医院肿瘤放疗科,山东潍坊261041

出　　处：《潍坊医学院学报》2022年第4期289-291,共3页Acta Academiae Medicinae Weifang

基　　金：潍坊市科技发展计划项目(项目编号:2019YX003)。

摘　　要：目的 分析单纯放疗与放疗联合化疗治疗初治鼻咽癌(NPC)的临床疗效。方法 选取潍坊市人民医院放疗科自2005年5月1日~2015年12月31日初治的NPC患者128例,共分为5个治疗组:单纯放疗组(n=51)、同步放化疗组(n=15)、同步放化疗+辅助化疗组(n=18)、单纯放疗+辅助化疗组(n=33)、夹心放化疗组(n=11)。分析全组生存率及比较5个治疗模式组的生存率差异。结果 同步放化疗和夹心放化疗组的总生存率(OS)与单独放疗组比较,差异均有统计学意义(P分别为0.03、0.04),并且与单纯放疗相比,同步放化疗和夹心放化疗的5年OS分别提高33.3%和43.4%.结论 与单纯放疗相比,同步放化疗可提高局部中晚期鼻咽癌患者的OS,且夹心放化疗可能成为Ⅱ~Ⅲ期患者的可供选择方案,该结果需要进一步的随机试验来验证。Objective To compare the clinical efficacies of intensity-modulated radiotherapy alone with that of chemoradiotherapy in the treatment of nasopharyngeal carcinoma.Methods A total of 128 patients with NPC retrospectively treated with IMRT between Jun 1,2005,and Dec 31,2015,in the Department of Radiation Oncology of Weifang People’s Hospital were analyzed.The patients were divided into 5 groups: intensity-modulated radiotherapy(n=51),concurrent chemoradiotherapy(n=15),concurrent chemoradiotherapy + adjuvant chemotherapy(n=18),intensity-modulated radiotherapy+adjuvant chemotherapy(n=33),and neoadjuvant chemotherapy+intensity-modulated radiotherapy+adjuvant chemotherapy(n=11).The study analyzed the clinical outcomes of the whole patients and differences in survival prognosis among 5 groups.Results A significant difference between OS for the concurrent chemoradiotherapy or neoadjuvant chemotherapy+intensity-modulated radiotherapy+adjuvant chemotherapy groups and intensity-modulated radiotherapy alone was observed over pairwised strata(P=0.03,0.04,respectively),and the 5-year OS in the concurrent chemoradiotherapy and neoadjuvant chemotherapy+intensity-modulated radiotherapy+adjuvant chemotherapy groups increased by 33.3% and 43.4% respectively.Conclusions To compared with intensity-modulated radiotherapy alone, concurrent chemoradiotherapy may improve the OS of initial patients with locoregionally moderate or advanced nasopharyngeal carcinoma, and neoadjuvant chemotherapy+intensity-modulated radiotherapy+adjuvant chemotherapy may equivalently be an alternative scheme.And additional randomized trials are warranted to conform the findings.

关 键 词：鼻咽肿瘤 调强放疗 化疗 治疗效果 

分 类 号：R739.6[医药卫生—肿瘤]