关注乳腺癌患者代谢相关脂肪性肝病的诊治  

Strengthening the diagnosis and treatment of metabolic associated fatty liver disease in breast cancer patients

作　　者：孔令泉[1] 田申 徐周 李浩 伍娟 李凡[1] 厉红元[1] 吴凯南[1] Kong Lingquan;Tian Shen;Xu Zhou;Li Hao;Wu Juan;Li Fan;Li Hongyuan;Wu Kainan(Department of Endocrine and Breast Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Thyroid and Breast Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]重庆医科大学附属第一医院内分泌乳腺外科,重庆400016 [2]四川省南充市川北医学院附属医院甲状腺乳腺外科,南充637000

出　　处：《中华内分泌外科杂志》2022年第5期520-524,共5页Chinese Journal of Endocrine Surgery

基　　金：国家自然科学基金(81372851)。

摘　　要：代谢相关脂肪性肝病(简称"代谢相关脂肪肝",metabolic associated fatty liver disease,MAFLD)是乳腺癌患者常见的伴随疾病,是患者化疗期间肝功损伤的主要原因之一,同时也是内分泌治疗或随访期间肝功损伤的重要原因,严重影响乳腺癌患者的生活质量和预后。非酒精性脂肪性肝病更名为代谢性脂肪性肝病,将原来的"排他性诊断"转变为"肯定性诊断",正视了代谢因素在脂肪性肝病发生发展过程中的不可忽视的作用,但目前临床重视不够。乳腺癌患者较正常人发生代谢紊乱的比例和风险更高,因此更应重视乳腺癌患者的代谢相关性脂肪性肝病的诊治。本文将探讨代谢相关脂肪性肝病新定义在乳腺癌伴随疾病全方位管理中的临床意义及其防治,以进一步提高乳腺癌患者的生活质量并改善预后。Metabolic-dysfunction associated fatty liver disease(MAFLD)is a common concomitant disease of breast cancer.It is one of the main causes of liver damage during chemotherapy and also an important cause of liver damage during endocrine therapy or follow-up,which seriously affects the quality of life and prognosis of breast cancer patients.Nonalcoholic fatty liver disease was renamed as MAFLD,which changed the original"exclusive diagnosis"to"inclusive diagnosis"and the non-negligible role of metabolic factors in the occurrence and development of fatty liver disease was recognized,but the clinical attention is not enough at present.More attention should be paid to the diagnosis and treatment of MAFLD in breast cancer patients because the proportion and risk of metabolic disorders are higher than that in general people.In this article,we will focus on the clinical significance,prevention and treatment of the new definition of MAFLD in the comprehensive management of concomitant diseases of breast cancer,so as to further improve the quality of life and prognosis of breast cancer patients.

关 键 词：乳腺癌 乳腺癌伴随疾病 代谢相关脂肪性肝病 非酒精性脂肪肝 乳腺肿瘤肝病学 

分 类 号：R737.9[医药卫生—肿瘤] R575.5[医药卫生—临床医学]