维生素A、D、E与抽动障碍的相关性研究  

Correlation between Vitamin A,D and E and Severity of Tic Disorder

作　　者：王爱珍[1] 张振宇[1] 李亚群[1] 田云龙 Wang Aizhen;Zhang Zhenyu;Li Yaqun;Tian Yunlong(Taizhou Hospital of Traditional Chinese Medicine,Jiangsu Taizhou 225300,China)

机构地区：[1]泰州市中医院,江苏泰州225300

出　　处：《儿科药学杂志》2022年第11期31-35,共5页Journal of Pediatric Pharmacy

基　　金：江苏省高层次卫生人才“六个一工程”拔尖人才项目,编号LGY2017034。

摘　　要：目的:探讨抽动障碍(TD)患儿血清中维生素A(VA)、维生素D(VD)、维生素E(VE)水平及其与抽动障碍的临床亚型、抽动症状严重程度的相关性,为临床更好地防治TD提供参考。方法:选取2018年1月至2020年7月泰州市中医院儿科门诊收治的TD患儿198例为TD组,同期就诊的健康儿童50例为对照组,检测VA、VD、VE水平并分析其与抽动症状的持续时间、严重程度的相关性。结果:TD组VA、VD水平均低于对照组,VA、VD缺乏或不足比例均高于对照组(P均<0.05);TD组VE水平与对照组比较差异无统计学意义,VE缺乏或不足比例与对照组比较差异无统计学意义(P均>0.05)。根据病程及抽动形式,TD可分为抽动秽语综合征(TS)、慢性抽动障碍(CTD)、短暂性抽动障碍(TTD)3个临床亚型。TS组VA水平低于CTD组及TTD组;TS组及CTD组VD水平低于TTD组;不同组间VE水平比较差异无统计学意义(P>0.05)。根据耶鲁综合抽动严重程度量表(YGTSS),将TD组分为轻度TD组和中重度TD组。轻度TD组、中重度TD组与对照组VA、VD水平比较差异有统计学意义(P<0.05);中重度TD组VA、VD水平低于轻度TD组和对照组(P<0.05);轻度TD组、中重度TD组与对照组VE水平比较差异无统计学意义(P>0.05)。TD患儿VA、VD水平与抽动症状严重程度呈负相关(P<0.05)。结论:TD患儿存在VA、VD缺乏或不足,TD患儿血清VA、VD水平与抽动障碍的临床亚型、抽动症状的严重程度具有相关性。Objective:To explore the serum levels of vitamin A(VA),vitamin D(VD)and vitamin E(VE)in children with tic disorder(TD)and its correlation with clinical subtypes and severity of tic symptoms,so as to provide evidence for better prevention and treatment of TD.Methods:From Jan.2018 to Jul.2020,198 children with TD in the pediatric outpatient department of Taizhou Hospital of Traditional Chinese Medicine were extracted as the TD group,and 50 healthy children in the same period were selected as the control group.The levels of VA,VD and VE were detected and its correlations with the duration and severity of tic symptoms were analyzed.Results:The levels of VA and VD in TD group were significantly lower than those in control group,and the proportion of children with VA and VD deficiency or insufficiency was higher than that in control group(P<0.05).There was no significant difference in the levels of VE between TD group and control group,and there was no significant difference in the proportion of VE deficiency or insufficiency between TD group and control group(P>0.05).Based on the duration of disease and form of TD,TD could be divided into three clinical subtypes:tic-syndrome(TS),chronic tic disorder(CTD)and transient tic disorder(TTD).The levels of VA in TS group were lower than those in CTD group and TTD group,the levels of VD in TS group and CTD group were lower than those in TTD group,there was no significant difference in the levels of VE among different groups(P>0.05).According to the Yale Global Tic Severity Scale(YGTSS),the TD group was divided into the mild TD group and moderate-to-severe TD group.There were statistically significant differences in serum levels of VA and VD among the mild TD group,moderate-to-severe TD group and control group(P<0.05).The levels of VA and VD in the moderate-to-severe TD group were lower than those in the mild TD group and control group(P<0.05).There was no significant difference in serum levels of VE among the mild TD group,moderate-to-severe TD group and control group(P>0.05).

关 键 词：抽动障碍 维生素A 维生素D 维生素E 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]