经导管动脉灌注吡柔比星、奥沙利铂、氟尿嘧啶治疗巨块型肝癌的临床效果  

Clinical Efficacy of Intraarterial Infusion of Pirarubicin,Oxaliplatin and Fluorouracil in the Treatment of Massive Liver Cancer

作　　者：陈旭 CHEN Xu(Minimally Invasive Surgery of Liver,Gallbladder and Pancreas,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院肝胆胰微创外科,河南郑州450000

出　　处：《河南医学研究》2022年第22期4074-4077,共4页Henan Medical Research

摘　　要：目的观察经导管肝动脉栓塞化疗(TACE)术中灌注吡柔比星、奥沙利铂、氟尿嘧啶治疗巨块型肝癌患者的效果。方法采用回顾性研究,收集2019年1月至2021年1月于郑州大学附属郑州中心医院接受治疗的71例原发性巨块型肝癌患者的临床资料,根据治疗方案分为观察组(37例)和对照组(34例)。观察组接受TACE中灌注吡柔比星、奥沙利铂、氟尿嘧啶治疗,对照组单纯接受肝动脉栓塞(TAE)治疗。比较两组治疗效果(疾病控制率和客观缓解率)、血清肿瘤标志物[甲胎蛋白(AFP)、癌胚抗原(CEA)、癌抗原199(CA199)]水平和不良反应发生情况。结果治疗3个月,两组患者的疾病控制率比较,差异无统计学意义(P>0.05),但观察组的客观缓解率高于对照组(P<0.05)。治疗前,两组血清AFP、CEA、CA199水平比较,差异无统计学意义(P>0.05)。治疗后,两组AFP、CEA、CA199水平均降低,观察组低于对照组(P<0.05)。治疗后,观察组不良反应发生率低于对照组(P<0.05)。结论TACE术中灌注吡柔比星、奥沙利铂、氟尿嘧啶治疗巨块型肝癌效果良好,且不良反应发生率较低。Objective To observe the effect of intra-arterial infusion of pirarubicin,oxaliplatin and fluorouracil during transcatheter arterial chemoembolization(TACE)in the treatment of massive liver cancer.Methods A retrospective study was conducted to collect the clinical data of 71 patients with primary massive liver cancer who were treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2019 to January 2021.According to the treatment scheme,they were divided into the observation group(37 cases)and the control group(34 cases).The observation group was treated with pirarubicin,oxaliplatin and fluorouracil perfusion in TACE,while the control group was treated with hepatic artery embolization alone.The therapeutic effect(disease control rate and objective remission rate),serum tumor markers alpha-fetal protein(AFP),carcinoembryonic antigen(CEA),cancer antigen 199(CA199)and adverse reactions were compared between the two groups.Results After 3 months of treatment,there was no statistical difference in disease control rate between the two groups(P>0.05),but the objective remission rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no statistical difference in serum AFP,CEA and CA199 levels between the two groups(P>0.05).After treatment,the levels of AFP,CEA and CA199 in both groups decreased,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Intraoperative infusion of pirarubicin,oxaliplatin and fluorouracil in TACE is effective in the treatment of massive liver cancer,and the incidence of adverse reactions is low.

关 键 词：巨块型肝癌 经导管肝动脉栓塞化疗 吡柔比星 奥沙利铂 氟尿嘧啶 

分 类 号：R735.7[医药卫生—肿瘤]