From dolphins to dogs:new opportunities to understand the role of P2X4 receptors in spinal cord injury and neuropathic pain  

作　　者：Reece A.Sophocleous Ronald Sluyter 

机构地区：[1]Illawarra Health and Medical Research Institute,Wollongong,NSW,Australia [2]Molecular Horizons and School of Chemistry and Molecular Bioscience,University of Wollongong,Wollongong,NSW,Australia

出　　处：《Neural Regeneration Research》2023年第7期1497-1498,共2页中国神经再生研究（英文版）

摘　　要：The P2X4 receptor belongs to the P2X receptor family of trimeric ligand-gated ion channels and was the first member of this family for which a crystal structure was obtained(Kawate et al.,2009).This structure confirmed the trimeric stoichiometry of P2X receptors and subsequent studies from the same group revealed the orthosteric binding site of the natural ligand adenosine 5′-triphosphate(ATP)in a cleft between each adjacent subunit(Hattori and Gouaux,2012).Now synonymous with structural descriptions of P2X receptors,these original studies described the structure of each P2X4 receptor subunit as that resembling a dolphin.

关 键 词：P2X4 subsequent 

分 类 号：R741[医药卫生—神经病学与精神病学]