PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss  

作　　者：Bei Fan Fei Lu Wei-Jia Du Jun Chen Xiao-Gang An Ren-Feng Wang Wei Li Yong-Li Song Ding-Jun Zha Fu-Quan Chen 

机构地区：[1]Department of Otolaryngology Head and Neck Surgery,Xijing Hospital,Fourth Military Medical University,Xi’an,Shaanxi Province,China

出　　处：《Neural Regeneration Research》2023年第7期1601-1606,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.81670925(to FQC),81870732(to DJZ),81800918(to WL),81900933(to YLS);Department of Science and Technology Key Industry Innovation Chain Social Development Field Fund of Shaanxi Province,No.2021ZDLSF02-12(to FQC);the Natural Science Foundation of Shaanxi Province,No.2019JM-009(to JC).

摘　　要：Studies have shown that phosphatase and tensin homolog deleted on chromosome ten(PTEN)participates in the regulation of cochlear hair cell survival.Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.However,whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains unclear.In this study,we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 hours.We found that PTEN expression was increased in the organ of Corti,including outer hair cells,inner hair cells,and lateral wall tissues.Intraperitoneal administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell ribbons.In addition,noise exposure decreased p-PI3K and p-Akt levels.Bisperoxovanadium preconditioning or PTEN knockdown upregulated the activity of PI3K-Akt.Bisperoxovanadium also prevented H_(2)O_(2)-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear explants.These findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss.

关 键 词：acoustic trauma Akt oxidative stress bisperoxovanadium cochlear hair cells loss inner hair cell ribbons loss noise exposure permanent threshold shift phosphatase and tensin homologue deleted on chromosome ten phosphatidylinositol 3 kinase siPTEN 

分 类 号：R741[医药卫生—神经病学与精神病学]