啮齿动物18F-FDG脑摄取影响因素的分析  

Analysis of the influencing factors of 18F-FDG uptake in the brain of rodents

作　　者：赵京序 崔曹哲 胡奕奕 武志芳[1] Zhao Jingxu;Cui Caozhe;Hu Yiyi;Wu Zhifang(Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2022年第9期561-564,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：小动物18F-氟脱氧葡萄糖(FDG)PET脑显像是脑科学基础研究的重要手段。在动物实验中, 饮食、麻醉、显像剂的给药途径、温度及光照等实验条件均会影响其脑部活动, 使脑灌注和代谢显像出现整体偏倚, 进而影响对脑认知功能的判断。笔者就啮齿动物显像研究中不同实验条件对18F-FDG脑摄取的影响进行综述, 为动物显像研究提供指导。18F-fluorodeoxyglucose(FDG)micro-PET brain imaging is an important means of basic research in brain science.In animal experiments,brain activity is affected by experimental conditions such as diet,anesthesia,administration route of imaging agents,temperature and light.As a result,there will be deviation in cerebral perfusion and metabolic imaging,which will affect the evaluation of brain cognitive function.The authors review the effects of different experimental conditions on the brain uptake of 18F-FDG in rodent imaging studies,and provide guidance for animal imaging research.

关 键 词：氟脱氧葡萄糖F18 正电子发射断层显像术 啮齿目 脑显像 

分 类 号：R741[医药卫生—神经病学与精神病学]