淋巴脉管间隙浸润与早期宫颈癌患者术后生存率和淋巴结转移的相关性分析  

Correlation analysis between lymph vascular space invasion and postoperative survival rate and lymph node metastasis in patients with early cervical cancer

作　　者：陈刚[1] 李娜[1] CHEN Gang;LI Na(Gynecology and Obstetrics Department,the First Hospital of Yulin,Yulin 716000,China)

机构地区：[1]榆林市第一医院妇产科,陕西榆林716000

出　　处：《临床医学研究与实践》2022年第35期17-20,共4页Clinical Research and Practice

摘　　要：目的分析淋巴脉管间隙浸润(LVSI)与早期宫颈癌(ECC)患者术后生存率和淋巴结转移的相关性。方法纳入2016年1月至2018年2月榆林市第一医院收治的260例ECC患者作为研究对象。采用单因素与多因素Cox回归分析探讨影响ECC患者3年生存率的因素;比较不同LVSI特征ECC患者的生存曲线;分析ECC患者LVSI与淋巴结转移的相关性。结果不同年龄、肿瘤直径、组织学类型、国际妇产科联盟(FIGO)分期以及术后辅助治疗的ECC患者3年生存率比较,差异无统计学意义(P>0.05);宫旁浸润、淋巴结转移、LVSI阳性、浸润深度≥1/2是影响ECC患者3年生存率的相关因素(P<0.05)。多因素Cox回归分析结果显示,宫旁浸润、淋巴结转移、LVSI阳性、浸润深度≥1/2均为影响ECC患者3年生存率的独立危险因素(P<0.05)。不同LVSI特征ECC患者的3年生存率、生存曲线、淋巴结转移阳性率比较,差异均具有统计学意义(P<0.05)。LVSI阳性、数量、分布均与淋巴结转移呈明显正相关(P<0.05)。结论LVSI与ECC患者术后生存率和淋巴结转移明显相关,可作为评估ECC患者预后的有效指标。临床中应加强对LVSI阳性ECC患者的重视,在术后开展相应的辅助性治疗,以改善患者预后。Objective To analysis of the correlation between lymph vascular space invasion(LVSI)and postoperative survival rate and lymph node metastasis in patients with early cervical cancer(ECC).Methods A total of 260 ECC patients admitted in the First Hospital of Yulin from January 2016 to February 2018 were included as the research objects.Univariate and multivariate Cox regression analysis was used to investigate the factors affecting the 3-year survival rate of ECC patients;the survival curves of ECC patients with different LVSI characteristics were compared,and the correlation between LVSI and lymph node metastasis in ECC patients was analyzed.Results There were no significant differences in 3-year survival rate of ECC patients with differents ages,tumor diameter,histological type,International Federation of Gynecology and Obstetrics(FIGO)stage and postoperative adjuvant therapy(P>0.05);parastatal invasion,lymph node metastasis,positive LVSI and infiltration depth≥1/2 were related factors affecting the 3-year survival rate of ECC patients(P<0.05).Multivariate Cox regression analysis results showed that parastatal invasion,lymph node metastasis,positive LVSI and infiltration depth≥1/2 were all independent risk factors affecting the 3-year survival rate of ECC patients(P<0.05).There were significant differences in 3-year survival rate,survival curve and positive rate of lymph node metastasis in ECC patients with different LVSI characteristics(P<0.05).LVSI positivity,quantity and distribution were positively correlated with lymph node metastasis(P<0.05).Conclusion LVSI is significantly related to postoperative survival rate and lymph node metastasis in ECC patients,and can be used as an effective indicator to assess the prognosis of ECC patients.Clinical attention should be paid to LVSI positive ECC patients,and corresponding adjuvant therapy should be carried out after surgery to improve the prognosis of patients.

关 键 词：淋巴脉管间隙浸润 早期宫颈癌 淋巴结转移 

分 类 号：R737.3[医药卫生—肿瘤]