通天口服液联合尤瑞克林治疗急性脑梗死的临床疗效研究  

Clinical effect of Tongtian oral liquid combined with urinary kallidinogenase in treatment of acute cerebral infarction

作　　者：邱树勋 邹薇 吴成吉[1] 戚询中[1] QIU Shuxun;ZOU Wei;WU Chengji;QI Xunzhong(Department of Neurology,First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154002,China)

机构地区：[1]佳木斯大学附属第一医院神经内科,黑龙江佳木斯154002

出　　处：《重庆医学》2022年第23期4048-4050,4055,共4页Chongqing medicine

摘　　要：目的观察通天口服液联合尤瑞克林治疗急性脑梗死(ACI)的临床疗效。方法选取2021年5月至2022年5月该院神经内科收治的ACI患者60例作为研究对象,采用随机数字表法分为观察组和对照组,每组30例。对照组静脉滴注尤瑞克林,常规进行抗血小板、调脂稳定斑块、调整血压、保持呼吸通畅、预防感染等对症支持治疗,观察组在采取对照组治疗方案基础上加用通天口服液治疗。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)日常生活活动能力(ADL)量表评分,血浆纤维蛋白原,血浆黏度,以及总有效率、不良反应发生率等。结果两组患者治疗后NIHSS评分均明显降低,且观察组患者治疗后NIHSS评分明显低于对照组,总有效率、ADL评分均明显高于对照组,血浆纤维蛋白原、血浆黏度下降幅度均明显大于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应率比较,差异无统计学意义(P>0.05)。结论通天口服液联合尤瑞克林治疗ACI疗效较好,且安全性较高。Objective To observe the clinical effect of Tongtian oral liquid combined with urinary kallidinogenase in the treatment of acute cerebral infarction(ACI).Methods Sixty patients with ACI admitted and treated in the neurology department of this hospital served as the research subjects and were divided into the control group and observation group according to the random number table method,30 cases in each group.The control group was treated by intravenous dripping of urinary kallidinogenase.The antiplatelet,stabilizing plaques by regulating lipids,regulating blood pressure,maintaining unobstructed breathing,preventing infection and other symptomatic treatments were routinely performed.The observation group was added with Tongtian oral liquid on the basis of the treatment scheme in the control group.The NIH Stroke Scale(NIHSS)and the activities of daily living(ADL)scores before and after treatment,plasma fibrinogen,plasma viscosity,total effective rate and incidence rate of adverse reactions before and after treatment were compared between the two groups.Results The NIHSS scores after treatment in the both groups were significantly decreased,moreover the NIHSS score after treatment in the observation group was significantly lower than that in the control group,the total effective rate and ADL score were significantly higher than those in the control group,the decrease ranges of plasma fibrinogen and plasma viscosity were significantly greater than those in the control group,and the differences were statistically significant(P<0.05).The occurrence rate of adverse reactions had no statistical difference between the two groups(P>0.05).Conclusion Tongtian oral liquid combined with urinary kallidinogenase in the treatment of acute cerebral infarction has good efficacy and high safety.

关 键 词：急性脑梗死 通天口服液 尤瑞克林 

分 类 号：R743[医药卫生—神经病学与精神病学]