Circulating tumour DNA in gastrointestinal cancer in clinical practice:Just a dream or maybe not?  

作　　者：Andrea Pretta Eleonora Lai Clelia Donisi Dario Spanu Pina Ziranu Valeria Pusceddu Marco Puzzoni Elena Massa Mario Scartozzi 

机构地区：[1]Medical Oncology Unit,University Hospital and University of Cagliari,Monserrato 09042,Cagliari,Italy

出　　处：《World Journal of Clinical Oncology》2022年第12期980-983,共4页世界临床肿瘤学杂志（英文版）

摘　　要：The evaluation of circulating tumor DNA(ctDNA)is increasingly integrated into the management of diagnosis and treatment of gastrointestinal cancer as it represents an innovative and minimally invasive biomarker that could allow us to reach clinical needs not met yet in randomized clinical trials.Recent research provided an interesting overview of the role of circulating tumor DNA in gastric,biliary,liver,pancreatic,and colorectal cancer.Data regarding upper gastrointestinal tumors are currently not practice changing.Tumor detection rates are low in the early stages,while in advanced stages ctDNA is useful for molecular tracking evaluation.Most of the evidence comes from colorectal cancer studies,where ctDNA was evaluated both in the early and advanced stages with the postsurgery minimal residual disease assessment and the response assessment,respectively.ctDNA qualifies as a promising tool in the era of precision medicine,with potential applications in the entire management of gastrointestinal cancer patients.Further evidence is needed to establish which setting may be influenced greatly by liquid biopsy in clinical practice.

关 键 词：Circulating tumor DNA Gastrointestinal cancer Liquid biopsy Esophageal cancer Gastric cancer Liver cancer Bile duct cancer Pancreatic cancer Colorectal cancer 

分 类 号：R735[医药卫生—肿瘤]