Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature  

作　　者：Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako Hideaki Hirai Naoto Nishii Kou Kayamori Tohru Ikeda Hiroyuki Harada 

机构地区：[1]Department of Oral and Maxillofacial Surgical Oncology,Division of Oral Health Science,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Bunkyo-ku 113-8549,Tokyo,Japan [2]Department of Oral Pathology,Division of Oral Health Science,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Bunkyo-ku 113-8549,Tokyo,Japan

出　　处：《World Journal of Clinical Cases》2022年第34期12742-12749,共8页世界临床病例杂志

摘　　要：BACKGROUND Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical course.Here,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the mouth.CASE SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was made.Gadolinium-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular space.Submandibular dissection,tumor resection,and reconstruction with a radial forearm flap were performed.The surgical specimen exhibited histologically low-grade MLS.Fused in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization analysis.The tumor was completely encapsulated and did not require additional treatment.Furthermore,no recurrence was reported 40 mo after surgery.CONCLUSION We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the mouth.Oftentimes,an MLS of the floor of the mouth lacks significant clinical findings and is often misdiagnosed.Although no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关 键 词：Myxoid liposarcoma Floor of mouth SURGERY Fluorescence in situ hybridization Sublingual space Case report 

分 类 号：R781[医药卫生—口腔医学]