Gingival enlargement induced by cyclosporine in Medullary aplasia:A case report  

作　　者：Giovanna Victory Rodríguez Alondra del Carmen Ruiz Gutiérrez Juan Ramón Gómez Sandoval Sarah Monserrat LomelíMartínez 

机构地区：[1]Periodontics Program,Department of Integrated Dentistry Clinics,Centro Universitario de Ciencias de la Salud,Universidad de Guadalajara,Guadalajara 44340,Jalisco,Mexico [2]Research Institute of Dentistry,Department of Integrated Dentistry Clinics,Centro Universitario de Ciencias de la Salud,Universidad de Guadalajara,Guadalajara 44340,Jalisco,Mexico [3]Department of Medical and Life Sciences,Centro Universitario de la Ciénega,Universidad de Guadalajara,Ocotlán 47810,Jalisco,Mexico

出　　处：《World Journal of Clinical Cases》2022年第34期12750-12760,共11页世界临床病例杂志

摘　　要：BACKGROUND Cyclosporine is an immunosuppressive agent used effectively for treatment of a rare haematological disorder known as medullary aplasia.This drug prevents several side effects,including gingival enlargement(GE)which compromises aesthetics,phonetics and chewing,and also predisposes patients to periodontitis.CASE SUMMARY This clinical case reports a 41-year-old woman who presented with cyclosporineinduced GE with underlying periodontitis and medullary aplasia.The management of the disease was approached through multidisciplinary strategy which allowed for accurate diagnosis and a strategic treatment based on the systemic condition and severity of oral pathology.The diagnosis was confirmed through histopathological analysis.The treatment was carried out in phases:Initial(oral hygiene motivation,mechanical supragingival plaque control,and non-surgical therapy);systemic treatment,corrective treatment,and maintenance.CONCLUSION Multidisciplinary management of cyclosporine-induced GE and medullary aplasia allows for correct diagnosis and effective treatment of this pathological expression through a phased therapeutic approach.

关 键 词：CYCLOSPORINE Gingival enlargement Medullary aplasia Periodontal surgery Case report 

分 类 号：R781[医药卫生—口腔医学]