高血压性脑出血患者超早期强化降血压治疗对血肿扩大的影响  

Effects of ultra-early intensive antihypertensive therapy on hematoma expansion in patients with hypertensive intracerebral hemorrhage

作　　者：徐楠 孙佳 XU Nan;SUN Jia(Dashiqiao Central Hospital,Dashiqiao 115100,China)

机构地区：[1]大石桥市中心医院,115100

出　　处：《中国现代药物应用》2022年第20期116-118,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析高血压性脑出血患者采用超早期强化降血压治疗对其血肿扩大的影响。方法68例高血压性脑出血患者,随机分为观察组和对照组,每组34例。对照组患者仅应用甘露醇在入院1 h内将收缩压控制在165 mm Hg(1 mm Hg=0.133 kPa)内,观察组患者应用尼莫地平或其他降压药在入院1 h内将收缩压控制在140 mm Hg内。比较两组患者入院24 h后的血肿量、收缩压和美国国立卫生研究院卒中量表(NIHSS)评分。结果入院24 h后,观察组患者的血肿量(6.03±2.11)ml少于对照组的(7.33±2.23)ml,收缩压(138.45±9.48)mm Hg、NIHSS评分(11.22±2.35)分低于对照组的(155.64±10.20)mm Hg、(12.35±2.20)分,差异均有统计学意义(P<0.05)。结论对高血压性脑出血患者进行超早期强化降血压治疗能够有效防止血肿扩大,降低收缩压,改善神经功能,值得临床推荐。Objective To analyze the effects of ultra-early intensive antihypertensive therapy on hematoma expansion in patients with hypertensive intracerebral hemorrhage.Methods A total of 68 patients with hypertensive intracerebral hemorrhage were randomly divided into observation group and control group,with 34 cases in each group.In the control group,the systolic blood pressure was controlled within 165 mm Hg(1 mm Hg=0.133 kPa)by applying mannitol only within 1 h of admission,and in the observation group,the systolic blood pressure was controlled within 140 mm Hg by applying nimodipine or other antihypertensive drugs within 1 h of admission.The hematoma volume,systolic blood pressure and National Institutes of Health Stroke Scale(NIHSS)score at 24 h after admission were compared between the two groups.Results At 24 h after admission,the hematoma volume(6.03±2.11)ml of the observation group was less than(7.33±2.23)ml of the control group;the systolic blood pressure(138.45±9.48)mm Hg and NIHSS score(11.22±2.35)points of the observation group were lower than(155.64±10.20)mm Hg and(12.35±2.20)of the control group;the differences were all statistically significant(P<0.05).Conclusion Ultra-early intensive antihypertensive therapy for patients with hypertensive intracerebral hemorrhage can effectively prevent hematoma expansion in,reduce systolic blood pressure and improve neurological function,which is worthy of clinical recommendation.

关 键 词：高血压性脑出血 超早期 降血压 血肿扩大 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]