局部晚期鼻咽癌局部残留后程推量放疗研究进展  

Research progress on dose-escalation at late-course of radiotherapy for locally advanced nasopharyngeal carcinoma patients with residual lesion

作　　者：黄叶才 罗杨坤[2] 张鹏[2] 王卫东[1,2] 张石川 冯梅[2,4] 许国辉 郎锦义[1,2] Huang Yecai;Luo Yangkun;Zhang Peng;Wang Weidong;Zhang Shichuan;Feng Mei;Xu Guohui;Lang Jinyi(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Radiation Oncology,Sichuan Cancer Hospital,Key Laboratory of Radiation Oncology of Sichun Province,Chengdu 610041,China;Department of Interventional Radiology,Sichuan Cancer Hospital,Chengdu 610041,China;Department of Oncology,Third Hospital of Sichuan Province,Chengdu 610041,China)

机构地区：[1]电子科技大学医学院,成都610054 [2]四川省肿瘤医院放疗中心,放射肿瘤四川省重点实验室,成都610041 [3]四川省肿瘤医院介入科,成都610041 [4]四川省第三人民医院,成都610041

出　　处：《中华放射肿瘤学杂志》2022年第11期1055-1058,共4页Chinese Journal of Radiation Oncology

基　　金：成都市科技局技术创新研发项目(2021-YF05-02112-SN);吴阶平医学基金会临床科研专项资助基金(320.6750.2021-22-15);四川省科技计划项目(2021YFS0172、2022YFS0047);四川省放射肿瘤学重点实验室开放基金(2021ROKF02)。

摘　　要：鼻咽癌是中国南方高发的头颈部恶性肿瘤,局部复发是局部晚期鼻咽癌主要失败模式之一。局部晚期鼻咽癌在接受根治性放疗后,残留病灶的后程推量放疗存在争议。在以新辅助化疗+同步放化疗为主流的局部晚期鼻咽癌现代治疗模式下,对于经过病理或影像学确诊为局部残留的晚期鼻咽癌患者,放射治疗后程是否进行推量放疗、推量时机、推量方式、剂量等尚未达成共识。如何准确判断是否残留,如何精确勾画推量靶区,采用何种剂量分割可最大限度提高肿瘤的局部控制,是鼻咽癌临床研究需要继续关注的方向。Nasopharyngeal carcinoma(NPC)is a common head and neck malignant tumor with high incidence in southern China.Local recurrence is one of the main failure modes of locally advanced NPC.The dose-escalation after radical radiotherapy for locally advanced NPC remains controversial.In the era of modern radiotherapy,the mainstream treatment mode of locally advanced NPC is neoadjuvant chemotherapy plus concurrent chemoradiotherapy.There is no consensus on whether to prescribe dose-escalation,how and when to conduct dose-escalation,how much dose to prescribe for patients with residual lesion proved by MRI or pathology.How to accurately determine the target volume and dose/fraction to maximize the local control of the tumor are the directions of clinical practice for locally advanced NPC,which remain to be further studied.

关 键 词：鼻咽肿瘤 放射疗法 后程推量 研究进展 

分 类 号：R739.63[医药卫生—肿瘤]