代谢综合征与前列腺癌进展之间相关性的Meta分析  

Meta-analysis of the association between metabolic syndrome and prostate cancer progression

作　　者：唐王琴 吕晓晴 王婕妤 吴景梅 宋永霞[1] 宋真[2] 洪静芳[1] TANG Wangqin;LV Xiaoqing;WANG Jieyu(School of Nursing,Anhui Medical University,Anhui,Hefei 230061,China)

机构地区：[1]安徽医科大学护理学院 [2]安徽医科大学第一附属医院,合肥230061

出　　处：《临床外科杂志》2022年第9期881-884,共4页Journal of Clinical Surgery

基　　金：安徽医科大学护理学院科研培育项目(hlqm2021046)。

摘　　要：目的 对代谢综合征与前列腺癌进展之间的相关性进行系统评价。方法 计算机检索多个数据库,时间限定为建库-2021年11月。首先收集关于代谢综合征与前列腺癌进展之间相关性的病例对照研究或队列研究,然后根据研究异质性采用适当的Meta分析方法。结果 共纳入10项病例对照研究,1项队列研究,包含13 207例病人。Meta分析结果显示,合并代谢综合征的病人前列腺癌根治术后Gleason评分(≥8分)高于非代谢综合征病人(OR=1.83,95%CI:1.44~2.33),病理T分期(≥T3)高于非代谢综合征病人(OR=1.95,95%CI:1.28~2.96),盆腔淋巴结转移发生率高于非代谢综合征病人(OR=1.96,95%CI:1.47~2.61),手术切缘阳性发生率高于非代谢综合征病人(OR=1.17,95%CI:1.04~1.33)。结论 与非代谢综合征病人比较,代谢综合征病人术后Gleason评分更高,病理T分期更高,盆腔淋巴结转移风险更大,手术切缘阳性发生率更高,表明代谢综合征与前列腺癌的进展之间具有一定的相关性。Objective To systematically evaluate the relationship between metabolic syndrome and prostate cancer progression.Methods Multiple databases were searched by computer, and the time was limited from establishment to November 2021.Case-control studies or cohort studies on the association between metabolic syndrome and prostate cancer progression were collected and meta-analyses were performed according to the results of heterogeneity.Results A total of 10 case-control studies and 1 cohort study were included, 13 207 patients were included.Meta-analysis showed that Gleason score(≥8) in patients with metabolic syndrome after radical prostatectomy was higher than that in patients with non-metabolic syndrome(OR=1.83,95%CI:1.44-2.33),and pathological T stage(≥T3) was higher than that in patients with non-metabolic syndrome(OR=1.95,95%CI:1.28-2.96),the incidence of pelvic lymph node metastasis was higher than that of non-metabolic syndrome patients(OR=1.96,95%CI:1.47-2.61),and the incidence of positive surgical margin was higher than that of non-metabolic syndrome patients(OR=1.17,95%CI:1.04-1.33).Conclusion Compared with patients without metabolic syndrome, patients with metabolic syndrome have higher Gleason score, higher pathological T-stage, higher risk of pelvic lymph node metastasis, and higher incidence of positive surgical margins, suggesting a certain correlation between metabolic syndrome and the progression of prostate cancer.

关 键 词：代谢综合征 前列腺癌 META分析 

分 类 号：R737.25[医药卫生—肿瘤] R589[医药卫生—临床医学]