Tertiary lymphoid structures as unique constructions associated with the organization,education,and function of tumor-infiltrating immunocytes  

作　　者：Jing CHEN Jian CHEN Lie WANG 

机构地区：[1]Department of Gastrointestinal Surgery,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China [2]Institute of Immunology and Bone Marrow Transplantation Center,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [3]Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China [4]Cancer Center,Zhejiang University,Hangzhou 310058,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第10期812-822,共11页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Zhejiang Provincial Key Project of Research and Development(No.2019C03043);the National Natural Science Foundation of China(Nos.32030035,31870874,32000623,and 32100693);the Zhejiang Provincial Natural Science Foundation(No.LZ21C080001)of China。

摘　　要：Tertiary lymphoid structures(TLSs)are formations at sites with persistent inflammatory stimulation,including tumors.These ectopic lymphoid organs mainly consist of chemo-attracting B cells,T cells,and supporting dendritic cells(DCs).Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response,delivering an augmented effect on the tumor microenvironment(TME).The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs.Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies.Several approaches have been developed to take advantage of intratumoral TLSs,either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.

关 键 词：Tertiary lymphoid structure(TLS) Tumor-infiltrating immunocyte Tumor microenvironment(TME) 

分 类 号：R730.2[医药卫生—肿瘤]