强直性脊柱炎发病机制及药物调控研究进展  

Advances in mechanisms for ankylosing spondylitis and drug regulation

作　　者：张曙琼 邵粉丽 孙洋 ZHANG Shu-qiong;SHAO Fen-li;SUN Yang(State Key Laboratory of Pharmaceutical Biotechnology,Dept of Biotechnology and Pharmaceutical Sciences,School of Life Sciences,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学生命科学学院生物技术与药学系,医药生物技术国家重点实验室,江苏南京210023

出　　处：《中国药理学通报》2022年第12期1761-1766,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81673436,81872877)。

摘　　要：强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎症性风湿病,属于自身免疫性疾病范畴,以由骶髂关节炎和其它中轴关节炎引起的炎性背痛,以及骨关节结构损伤和病理性新骨形成为特征。严重的关节及关节外病变给AS患者的生活造成了极大的不便与痛苦,因此,近年来研究者对AS的发病机制及药物调控研究愈发重视。目前,广受认可的AS发病机制包括遗传因素、免疫因素以及经典成骨通路的影响,各机制间相互联系,共同导致AS疾病进展。针对其发病机制,一系列靶向炎症的治疗药物不断涌现,包括肿瘤坏死因子抑制剂、白细胞介素-17/白细胞介素-23(IL-17/IL-23)单克隆抗体以及一些缓解疾病症状的抗风湿类药物等。此外,该文也强调了靶向病理性成骨的治疗必要性。Ankylosing spondylitis(AS)is a chronic inflammatory rheumatic disease,which belongs to the category of autoimmune diseases and is characterized by inflammatory back pain owing to sacroiliitis and other axial arthritis,as well as bone structural damage and pathological new bone formation.Severe joint and extra-joint lesions have caused great inconvenience and pain,from which patients with ankylosing spondylitis suffer a lot.Therefore researchers have paid more attention to the pathogenesis and drug regulation of ankylosing spondylitis in recent years.At present,the universally recognized pathogenesis of AS includes the influence of genetic factors,immune factors and classical osteogenic pathways,all of which are interrelated and synergistically lead to the progression of AS.In view of its pathogenesis,a series of drugs targeting inflammation have been emerging,including tumor necrosis factor inhibitors,interleukin-17/interleukin-23(IL-17/IL-23)monoclonal antibodies and some anti-rheumatism drugs to relieve the symptoms.Moreover,we also herein highlight the therapeutic necessity of targeting pathological osteogenesis.

关 键 词：强直性脊柱炎 发病机制 遗传 炎症 新骨形成 治疗药物 

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