Controversial usages of kratom(Mitragyna speciosa):For good or for evil  

作　　者：Murtadha Basheer Rana Khudhair Jasim Gam Lay Harn 

机构地区：[1]School of Pharmaceutical Sciences,Universiti Sains Malaysia,Minden 11800,Penang,Malaysia

出　　处：《World Journal of Pharmacology》2022年第3期16-26,共11页世界药理学杂志

摘　　要：Kratom(Mitragyna speciosa)is a plant that grows well in tropical climates such as in Southeast Asia.Traditionally,people discovered it possessed a stimulating effect that relieved tiredness.Furthermore,it contains analgesic and medicinal properties for the treatment of pain,diarrhea,muscle discomfort,and blood pressure and to enhance stamina.Nevertheless,long term or regular consumption of kratom leads to addiction.This is because the main alkaloid of kratom,mitragynine,binds to opioid receptors and exerts a euphoric effect similar to that of morphine,which may lead to death.Due to this reason,kratom has been listed as a regulated substance in many countries including the United States,Thailand,Malaysia,Bhutan,Finland,Lithuania,Denmark,Poland,Sweden,Australia,and Myanmar.Usages of kratom carry two pharmacological effects depending on dosage.Low-dose kratom exerts a stimulating effect that refreshes the user.Highdose kratom exerts sedative effects that can lead to addiction similar to that of morphine.Despite the euphoric effect of kratom,the beneficial values of kratom to human health is indisputable.Therefore,a complete banning of kratom may cause a loss to pharmaceutical industry.Rather,a controlled or selective usage of kratom will be a better choice.

关 键 词：KRATOM OPIOID Pharmacological actions TOXICITY ADDICTION Herbal plant 

分 类 号：O62[理学—有机化学]