Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice:Highlighting effects on behaviour,oxidative stress,and neuroinflammation  

作　　者：Adejoke Yetunde Onaolapo Hameed Sulaiman Anthony Tope Olofinnade Olakunle James Onaolapo 

机构地区：[1]Department of Anatomy,Ladoke Akintola University of Technology,Oyo State 234,Nigeria [2]Department of Pharmacology,Ladoke Akintola University of Technology,Oyo State 234,Nigeria

出　　处：《World Journal of Pharmacology》2022年第3期27-47,共21页世界药理学杂志

摘　　要：BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract either as a sole agent or as an adjunct in depression therapy.METHODS Adult mice were assigned into three main groups based on the neurobehavioural models;and each main group had ten treatment groups of 10 mice each.Treatment groups were:Vehicle control group,oral sertraline(SERT)group,two groups fed SILY)-supplemented diet(SILY at 140 and 280 mg/kg of feed,respectively),dexamethasone(DEX;i.p.)group,DEX/SERT group,two groups of DEX/SILY(SILY at 140 and 280 mg/kg of feed,respectively),and another two groups of(SERT/DEX/SILY)(SILY at 140 and 280 mg/kg of feed,respectively,plus i.p.DEX plus SERT).Duration of the study was 7 wk,and treatments were administered daily.RESULTS SILY(alone)increased body weight,open field locomotor activity,rearing,and grooming;it also enhanced spatial working memory while decreasing anxietyrelated behaviours and behavioural despair.SILY also improved antioxidant status while decreasing lipid peroxidation,acetylcholinesterase activity,and inflammatory markers.Neuronal integrity of the cerebral cortex and hippocampus was preserved.Overall,when administered alone or with SERT,SILY counteracted DEX-induced behavioural and biochemical changes while preserving neuromorphological integrity.CONCLUSION In conclusion,SILY is beneficial in mitigating DEX-induced central nervous system and other related changes in mice.

关 键 词：Behavioural despair Depression Mental Health Neurobehaviour Neuromorphology 

分 类 号：R57[医药卫生—消化系统]