ⅢC1期宫颈癌预后影响因素分析  

Influencing factors of prognosis of cervical cancer in stage ⅢC1

作　　者：张威[1] 刘丽雅[1] 冯文龙[1] 蔡明博 韩丽萍[1] ZHANG Wei;LIU Liya;FENG Wenlong;CAI Mingbo;HAN Liping(Department of Gynecology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院妇科,郑州450052

出　　处：《郑州大学学报（医学版）》2022年第6期826-829,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200346)。

摘　　要：目的:探讨ⅢC1期宫颈癌预后影响因素。方法:收集2012年7月至2016年10月在郑州大学第一附属医院接受手术治疗的117例ⅢC1期宫颈癌患者的临床资料,包括年龄、组织学类型、原发肿瘤直径、宫颈间质浸润深度、淋巴脉管间隙是否浸润、分化程度、阴道壁上2/3是否侵犯、淋巴结比率(LNR)、辅助治疗类型等。针对不同临床特征患者Kaplan-Meier法绘制无病生存期和总生存期的生存曲线。采用Cox回归模型筛选无病生存和总生存影响因素。结果:Cox回归结果显示,LNR>0.1、肿瘤直径>4 cm、术后无放疗及阴道壁上2/3侵犯是ⅢC1期宫颈癌无病生存的危险因素,HR(95%CI)分别为5.211(2.502~10.851)、2.762(1.431~5.333)、3.004(1.471~6.314)、2.151(1.115~4.149);也是总生存的危险因素,HR(95%CI)分别为4.846(2.165~10.846)、2.303(1.103~4.809)、3.975(1.873~8.436)、2.606(1.241~5.471)。结论:LNR>0.1、肿瘤直径>4 cm、术后无放疗及阴道壁上2/3侵犯是ⅢC1期宫颈癌预后危险因素。Aim:To explore the influencing factors of prognosis of stage ⅢC1 cervical cancer.Methods:The clinical data of 117 patients with ⅢC1 cervical cancer treated in the Department of Gynecology of the First Affiliated Hospital of Zhengzhou University from July 2012 to October 2016 were collected,including age,histological type,primary tumor diameter,depth of cervical interstitial infiltration,lymphovascular space invasion,degree of differentiation,upper part(2/3) of the vaginal invasion,lymph node ratio(LNR),type of adjuvant therapy,etc..Kaplan-meier method was used to plot the survival curves of disease-free survival(DFS) and overall survival(OS)of the patients with different clinical characteristics.The influencing factors of DFS and OS were screened by Cox regression model.Results:Cox regression results showed LNR>0.1,tumor diameter>4 cm,no radiotherapy,and upper part(2/3) of the vaginal invasion were the risk factors for DFS,HR(95%CI) were 5.211(2.502-10.851),2.762(1.431-5.333),3.004(1.471-6.314),2.151(1.115-4.149),respectively;and for OS,HR(95%CI) were 4.846(2.165-10.846),2.303(1.103-4.809),3.975(1.873-8.436),2.606(1.241-5.471),respectively.Conclusion:LNR>0.15,tumor diameter>4 cm,no radiotherapy,and upper part(2/3) of the vaginal invasion are the risk factors for prognosis of cervical cancer in stage ⅢC1.

关 键 词：宫颈癌 ⅢC1期 预后影响因素 无病生存期 总生存期 

分 类 号：R737.33[医药卫生—肿瘤]