罗布麻茶改善睡眠功能实验研究  

Apocynum venetum Tea Improves Animal Sleep

作　　者：何伟 王莉 刘磊 黄景凤 李治建 HE Wei;WANG Li;LIU Lei;HUANG Jingfeng;LI Zhijian(Altay Gaubau Tea Co.,Ltd.,Altay 836500,China;Urumqi Branch,Altay Gaubau Tea Co.,Ltd.,Urumqi 830015,China;Xinjiang Engineering Technology Research Center for Apocynum venetum,Altay 836500,China;Xinjiang Institute of Traditional Uyghur Medicine,Urumqi 830049,China)

机构地区：[1]阿勒泰戈宝茶股份有限公司,阿勒泰836500 [2]阿勒泰戈宝茶股份有限公司乌鲁木齐分公司,乌鲁木齐830015 [3]新疆罗布麻工程技术研究中心(红麻),阿勒泰836500 [4]新疆维吾尔自治区维吾尔药研究所,乌鲁木齐830049

出　　处：《世界中医药》2022年第23期3356-3359,共4页World Chinese Medicine

基　　金：新疆维吾尔自治区重大科技专项项目(2016A03006,2016A03006-2,2016A03006-4)。

摘　　要：目的:研究罗布麻茶改善睡眠功效。方法:通过小鼠经口连续灌胃给予高剂量、中剂量和低剂量3种不同剂量的罗布麻茶30 d,然后对给药后小鼠的戊巴比妥钠直接睡眠的实验、戊巴比妥钠阈下剂量的催眠实验、巴比妥钠睡眠潜伏期实验对罗布麻茶功效进行评价。结果:与阴性对照组比较,戊巴比妥钠诱导的小鼠睡眠时间罗布麻茶高剂量组显著延长(P<0.01),睡眠潜伏期明显减短(P<0.01);罗布麻茶中剂量组小鼠睡眠时间延长(P<0.05);直接睡眠实验入睡动物个数、睡眠时间及戊巴比妥钠入睡发生率罗布麻茶高剂量组、罗布麻茶中剂量组、罗布麻茶低剂量组与阴性对照组比较差异无统计学意义(P>0.05);各项实验小鼠体质量罗布麻茶高剂量组、罗布麻茶中剂量组、罗布麻茶低剂量组与阴性对照组比差异无统计学意义(P>0.05)。结论:罗布麻茶具有改善睡眠的功效。Objective:To explore the effect of A.venetum tea(AVT)on sleep of mice.Methods:Mice received(oral administration)high-dose,medium-dose,and low-dose AVT for 30 days.Then,sodium pentobarbital-induced sleep experiment,hypnosis experiment under subthreshold dose of sodium pentobarbital,and barbital sodium sleep latency experiment were adopted to evaluate the function of AVT.Results:The sodium pentobarbital-induced sleep time was longer(P<0.01)and sleep latency was shorter(P<0.01)in the high-dose AVT group than in the negative control group.The sleep time in the medium-dose AVT group was longer than the negative control group(P<0.05).The number of sleeping mice,sleep time,and occurrence of sodium pentobarbital-induced sleep in the negative control group were insignificantly different from those in the three AVT groups(P>0.05).There was no significant difference in body weight between the negative control group and the three AVT groups(P>0.05).Conclusion:AVT had the effect of improving sleep.

关 键 词：罗布麻茶 小鼠 戊巴比妥钠 巴比妥钠 催眠实验 潜伏期 功效评价 改善睡眠 

分 类 号：R285.5[医药卫生—中药学]