神经元细胞轴浆运输障碍与阿尔茨海默病关系的研究进展  

Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease

作　　者：于明慧 薛傲 徐红丹[1] 王岩 林雪 杨波[1] 孙慧峰[1] 张宁[1,2] Yu Minghui;Xue Ao;Xu Hongdan;Wang Yan;Lin Xue;Yang Bo;Sun Huifeng;Zhang Ning(College of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040,China;不详)

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040 [2]黑龙江中医药大学佳木斯学院,佳木斯154007

出　　处：《新医学》2022年第12期874-877,共4页Journal of New Medicine

基　　金：国家自然科学基金面上项目(82174007);国家自然科学基金青年科学基金项目(82003975);黑龙江省属高校科技成果研发、培育项目(TSTAU-C2018020);黑龙江中医药大学基金项目(2018RCD19,2018jkcy05,2019BJP01)

摘　　要：阿尔茨海默病号称“全球十大杀手”之一,因目前尚没有治愈的办法,其早期的病理变化备受关注。轴浆运输障碍已被报道为多种神经退行性疾病的早期病理特征,然而引起轴浆运输障碍的因素有很多,该文从驱动蛋白、微管及线粒体等3个方面引起的轴浆运输障碍与阿尔茨海默病的关系进行探讨,旨在深入研究神经元轴浆运输机制、为防治阿尔茨海默病提供新的思路。Alzheimer’s disease is known as one of the"top ten killers in the world".Due to lack of effective therapy at present,early pathological changes have captivated widespread attention.Axonal transport dysfunction has been reported as an early pathological feature of many neurodegenerative diseases.However,multiple factors can cause axonal transport dysfunction.In this article,the relationship between axonal transport dysfunction caused by kinesins,microtubules and mitochondria and Alzheimer’s disease was discussed,aiming to provide new ideas for the prevention and treatment of Alzheimer’s disease by in-depth study on axonal transport mechanism of neure.

关 键 词：轴浆运输障碍 阿尔茨海默病 驱动蛋白 微管 线粒体 

分 类 号：R749.16[医药卫生—神经病学与精神病学]