砭石疗法通过调控神经递质改善中青年慢性失眠患者失眠症状的临床研究  

Clinical study of Bian-shi therapy to mitigate insomnia symptoms in young and middle-aged patients with chronic insomnia by regulating neurotransmitters

作　　者：焦勇钢[1] 林宋斌 丘婉怡 张胜明[3] Jiao Yonggang;Lin Songbin;Qiu Wanyi;Zhang Shengming(Department of Neurology,Guangdong Second Provincial General Hospital,Guangzhou 510317,China;不详)

机构地区：[1]广东省第二人民医院神经内科,广州510317 [2]广东省第二人民医院传统医学与运动伤害康复研究所,广州510317 [3]广东省第二人民医院体检科,广州510317

出　　处：《新医学》2022年第12期904-907,共4页Journal of New Medicine

基　　金：广东省中医药管理局科研基金(20211019)。

摘　　要：目的探讨砭石疗法改善中青年慢性失眠患者睡眠质量的机制。方法将40例中青年慢性失眠患者随机分为西药组与砭石组各20例。西药组口服佐匹克隆片(7.5 mg、睡前口服),砭石组给予安慰剂及砭石疗法治疗(每次40 min,每周1次,共4次)。治疗30 d后,分析2组治疗前后匹兹堡睡眠质量指数(PSQI)以及血清褪黑素、乙酰胆碱、去甲肾上腺素水平的变化,并比较2组的差异。结果治疗30 d后,2组PSQI各项因子评分均较治疗前下降(P均<0.05);与西药组相比,砭石组的PSQI各项因子评分下降更明显(P均<0.05)。治疗30 d后,2组的血清褪黑素、乙酰胆碱水平均高于治疗前,而去甲肾上腺素水平低于治疗前(P均<0.05);与西药组相比,砭石组的血清褪黑素、乙酰胆碱水平更高,去甲肾上腺素水平更低(P均<0.05)。结论砭石治疗可改善中青年慢性失眠患者的睡眠质量,且效果优于佐匹克隆片。砭石治疗改善慢性失眠症状的机制可能涉及多种神经递质。Objective To investigate the therapeutic mechanism of Bian-shi therapy in improving sleep quality in young and middle-aged patients with chronic insomnia.Methods 40 young and middle-aged patients with chronic insomnia were randomly divided into the western medicine group(n=20)and Bian-shi group(n=20).In the western medicine group,patients were orally treated with zopiclone(7.5 mg,oral administration before bedtime),and those in the Bian-shi group were treated with placebo and Bian-shi therapy(once a week,40 min a time,4 times in total).The changes of Pittsburgh Sleep Quality Index(PSQI),and serum melatonin,acetylcholine and norepinephrine before and after 30 d treatment were analyzed and compared between two groups.Results After 30 d treatment,PSQI scores were significantly lower compared with those before treatment in two groups(both P<0.05).In the Bian-shi group,PSQI scores were more significantly decreased than those in the western medicine group(all P<0.05).After 30 d treatment,serum levels of melatonin and acetylcholine were significantly higher,whereas norepinephrine levels were significantly lower than those before treatment in two groups(all P<0.05).In the Bian-shi group,serum levels of melatonin and acetylcholine were significantly higher,whereas norepinephrine levels were significantly lower compared with those in the western medicine group(all P<0.05).Conclusions Bian-shi therapy can effectively improve the sleep quality of young and middle-aged patients with chronic insomnia,which yields higher clinical efficacy than that of zopiclone tablets.Multiple neurotransmitters may be involved in the mechanism of Bian-shi therapy to mitigate chronic insomnia symptoms.

关 键 词：砭石治疗 慢性失眠 睡眠质量 神经递质 

分 类 号：R740[医药卫生—神经病学与精神病学]