急性髓系白血病患者血浆lncRNA SNHG16、miR-183-5p水平与病理特征和预后的关系  

Relationships between plasma lncRNA SNHG16,miR-183-5p and pathological features and prognosis in patients with acute myeloid leukemia

作　　者：尹薇[1] 王欣[1] YIN Wei;WANG Xin(Department of Hematology,Suining Central Hospital,Suining 629000,China)

机构地区：[1]遂宁市中心医院血液内科,四川遂宁629000

出　　处：《山东医药》2022年第34期1-5,共5页Shandong Medical Journal

基　　金：四川省卫生健康科研课题普及项目(19PJ0283)。

摘　　要：目的探讨急性髓系白血病(AML)患者血浆长链非编码RNA小核仁RNA宿主基因16(lncRNASN⁃HG16)、微小RNA-183-5p(miR-183-5p)水平与病理特征和预后的关系。方法选取93例AML患者为AML组,选取同期40例体检中心查体健康者为对照组,采用qPCR法检测血浆lncRNASNHG16、miR-183-5p水平。采用Pearson相关法分析AML患者血浆lncRNASNHG16与miR-183-5p水平的相关性及与病理特征的关系。Kaplan-Meier法绘制不同血浆lncRNASNHG16、miR-183-5p水平AML患者生存曲线。结果AML组血浆lncRNASNHG16水平高于对照组,miR-183-5p水平低于对照组(P均<0.01)。Pearson相关性分析显示,AML患者血浆lncRNASNHG16与miR-183-5p水平呈负相关(r=-0.704,P<0.01)。不同白细胞计数、骨髓原始细胞比率、预后危险分层AML患者血浆lncRNASNHG16、miR-183-5p水平比较差异有统计学意义(P均<0.05)。中位随访25个月,3年总生存率为54.84%(51/93)。Kaplan-Meier生存曲线分析显示,lncRNASNHG16高水平者3年总生存率低于lncRNASNHG16低水平者,miR-183-5p高水平者3年总生存率高于miR-183-5p低水平者(P均<0.05)。结论AML患者血浆lncRNASNHG16水平升高,miR-183-5p水平降低,二者水平与白细胞计数、骨髓原始细胞比率、预后危险分层和患者预后有关。Objective To investigate the relationships between plasma long non-coding RNA small nucleolar RNA host gene 16(lncRNA SNHG16)and microRNA-183-5p(miR-183-5p)expression and pathological features and prognosis of patients with acute myeloid leukemia(AML).Methods Ninety-three patients with AML were selected as the AML group,and 40 healthy subjects from the physical examination center were selected as the control group during the same period.The qPCR was used to detect plasma lncRNA SNHG16 and miR-183-5p expression.Pearson correlation coef⁃ficient was used to analyze the correlation between plasma lncRNA SNHG16 and miR-183-5p expression in AML patients and the relationship with pathological features.Kaplan-Meier method was used to plot the survival curves of AML patients with different plasma lncRNA SNHG16 and miR-183-5p expression.Results Plasma lncRNA SNHG16 expression was higher in the AML group than in the control group,and miR-183-5p expression was lower than that in the control group(both P<0.01).Pearson correlation analysis showed that plasma lncRNA SNHG16 was negatively correlated with miR-183-5p expression in AML patients(r=-0.704,P<0.01).Significant differences were found in the plasma lncRNA SN⁃HG16 and miR-183-5p expression levels in AML patients with different white blood cell counts,bone marrow primitive cell ratios and prognostic risk stratification(all P<0.05).The median follow-up was 25 months and the 3-year overall survival rate was 54.84%(51/93).Kaplan-Meier survival curve analysis showed that the overall survival rate of the high lncRNA SNHG16 expression group was lower than that of the low lncRNA SNHG16 expression group,and the overall survival rate of the high miR-183-5p expression group was higher than that of the low miR-183-5p expression group(all P<0.05).Con⁃clusions Plasma lncRNA SNHG16 is highly expressed and miR-183-5p is low expressed in AML patients,and their ex⁃pression levels are associated with white blood cell counts,bone marrow primitive cell ratios and prognostic risk strat

关 键 词：急性髓系白血病 长链非编码RNA小核仁RNA宿主基因16 微小RNA-183-5p 临床病理特征 预后 

分 类 号：R733.7[医药卫生—肿瘤]