脂质代谢在脑胶质瘤中的研究进展  

Research progress of lipid metabolism in glioma

作　　者：王凯旋 张世渊[2] 吉宏明[2] 胡昌辰[2] WANG Kai-xuan;ZHANG Shi-yuan;JI Hong-ming(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第五临床医学院,太原030001 [2]山西省人民医院神经外科

出　　处：《临床神经外科杂志》2022年第6期715-720,共6页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金项目(30901774);山西省自然科学基金项目(2014011038-2);山西省重点研发计划项目(国际合作)(201803D421055);山西省留学人员科技活动择优资助项目(2018014);山西省人民医院省级专项配套经费科研项目(sj20019003)。

摘　　要：胶质瘤是发病率、病死率最高的一种中枢神经系统肿瘤。目前来说,尽管进行及时地综合治疗,胶质瘤仍然预后差,复发率高,对于高级别胶质瘤来说,情况更是如此。代谢重编程作为癌症的突出特征之一,在胶质瘤中也尤为明显。与Warburg效应和谷氨酰胺代谢一样,脂质代谢在癌症中被大量重新编程。在胶质瘤中,对脂质代谢过程中的相关酶和蛋白进行调节,如单酰基甘油酯脂肪酶、脂肪酸结合蛋白、固醇调节元件结合蛋白等,可为胶质瘤治疗提供新的标靶。Glioma is a central nervous system primary tumor with the highest incidence rate and mortality.At present,despite timely comprehensive treatment,glioma still has poor prognosis and high recurrence rate,especially for high-grade glioma.Metabolic reprogramming is one of the prominent features of cancer,especially in glioma.Like the Warburg effect and glutamine decomposition,lipid metabolism is heavily reprogrammed in cancer.In glioma,the regulation of related enzymes and proteins in the process of lipid metabolism,such as monoacylglycerol lipase,fatty acid binding protein and sterol regulatory element binding protein,can provide new targets for glioma treatment.

关 键 词：脂质代谢 胶质瘤 脂肪酸 胆固醇 

分 类 号：R739.41[医药卫生—肿瘤]