益生菌制品消费与缺血性卒中患者卒中后抑郁的相关性  

Correlation between consumption of probiotic products and post-stroke depression in patients with ischemic stroke

作　　者：祁智 朱丹 王爱莉 王施 俞海萍 Qi Zhi;Zhu Dan;Wang Aili;Wang Shi;Yu Haiping(School of Medicine,Tongji University,Shanghai 200092,China;Department of Neurology,the Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China;Nursing Department,East Hospital Affiliated to Tongji University,Shanghai 200120,China)

机构地区：[1]同济大学医学院,上海200092 [2]海军军医大学第三附属医院神经内科,上海200438 [3]同济大学附属东方医院护理部,上海200120

出　　处：《国际脑血管病杂志》2022年第7期489-493,共5页International Journal of Cerebrovascular Diseases

摘　　要：目的探讨益生菌制品消费水平与卒中后抑郁(post-stroke depression, PSD)的相关性。方法前瞻性纳入2021年5月至2022年1月在海军军医大学第三附属医院神经内科就诊的缺血性卒中患者。根据抑郁自评量表(self-rating depression scale, SDS)分为PSD组(SDS评分≥53分)和非PSD组(SDS评分<53分)。比较两组人口统计学资料、临床资料及益生菌制品消费水平确定PSD的影响因素。采用多因素logistic回归分析确定PSD与益生菌制品消费水平之间的独立相关性。结果共纳入120例缺血性卒中患者, PSD组39例(32.5%), 非PSD组81例(67.5%)。多变量logistic回归分析显示, 校正潜在混杂因素后, 梗死严重程度(优势比1.276, 95%置信区间1.138~1.432;P<0.001)和益生菌制品消费水平(优势比0.300, 95%置信区间0.098~0.916;P=0.035)是PSD的独立影响因素。结论益生菌制品消费水平是PSD的独立保护因素, 高益生菌制品消费水平与PSD发生率较低相关。Objective To investigate the correlation between the consumption level of probiotic products and post-stroke depression(PSD).Methods Patients with ischemic stroke visited the Department of Neurology,the Third Affiliated Hospital of Naval Medical University from May 2021 to January 2022 were prospectively enrolled.According to self-rating depression scale(SDS),they were divided into PSD group(SDS score≥53)and non-PSD group(SDS score<53).The influence factors of PSD were determined by comparing the demographic data,clinical data and consumption level of probiotic products between the two groups.Multivariate logistic regression analysis was used to determine the independent correlation between PSD and the consumption level of probiotic products.Results A total of 120 patients with ischemic stroke were enrolled,including 39(32.5%)in the PSD group and 81(67.5%)in the non-PSD group.Multivariate logistic regression analysis showed that after adjusting for potential confounding factors,the severity of infarction(odds ratio 1.276,95%confidence interval 1.138-1.432;P<0.001)and the consumption level of probiotic products(odds ratio 0.300,95%confidence interval 0.098-0.916;P=0.035)were the independent influencing factors of PSD.Conclusion The consumption level of probiotic products is an independent protective factor for PSD,and higher consumption level of probiotic products is associated with lower PSD incidence.

关 键 词：卒中 脑缺血 抑郁症 益生菌 胃肠道微生物群 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]