2010年-2021年中国人群肺癌危险因素及易感基因GSTM1多态性的Meta分析  

Risk factors and susceptibility gene GSTM1 polymorphism of lung cancer in Chinese population from 2010 to 2021:A Meta-analysis

作　　者：孙鑫 孙凯旋 张涛 廖成功 刘理礼 张贺龙 SUN Xin;SUN Kaixuan;ZHANG Tao;LIAO Chenggong;LIU Lili;ZHANG Helong(Department of Oncology,Tangdu Hospital,Air Force Medical University,Shaanxi Xi'an 710038,China;Cancer Institute,Air Force Medical University,Shaanxi Xi'an 710038,China)

机构地区：[1]空军军医大学唐都医院肿瘤科,陕西西安710038 [2]空军军医大学肿瘤研究所,陕西西安710038

出　　处：《现代肿瘤医学》2022年第23期4259-4268,共10页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81572251)。

摘　　要：目的:探寻近十年中国人群肺癌发病与相关危险因素及GSTM1基因多态性的关系。方法:检索Pubmed、Embase、Web of Science、Cochrane Library、CNKI、CBM、维普和万方数据库自2010年01月01日至2021年08月01日有关国内人群的肺癌发病危险因素的病例对照研究,采用NOS量表评分筛选文献并提取肺癌相关危险因素,利用ReviewManager5.3和Stata16.0软件进行Meta分析。结果:共纳入48篇文献,总计纳入45904例研究对象。在剔除影响异质性的研究后,应用固定效应模型得到Meta分析结果为:吸烟[OR(95%CI)=3.29(3.02~3.57)]、被动吸烟[OR(95%CI)=2.31(2.03~2.62)]、肿瘤家族史[OR(95%CI)=4.36(3.30~5.77)]、规律锻炼身体[OR(95%CI)=0.41(0.34~0.48)]、常吃蔬菜水果[OR(95%CI)=0.41(0.35~0.48)]、饮茶[OR(95%CI)=0.66(0.60~0.73)]、呼吸系统疾病史[OR(95%CI)=2.89(2.24~3.73)]、情绪压抑[OR(95%CI)=2.78(2.25~3.44)]、油烟接触[OR(95%CI)=3.45(2.73~4.35)]、住宅附近有污染工厂[OR(95%CI)=1.87(1.55~2.26)]和GSTM1缺失[OR(95%CI)=1.87(1.66~2.11)]为肺癌发病影响因素。结论:近十年国内人群肺癌主要危险因素有:吸烟、被动吸烟、肿瘤家族史、呼吸系统疾病史、情绪压抑、油烟接触、住宅附近有污染工厂和GSTM1缺失;保护因素有:规律锻炼身体、常吃蔬菜水果、饮茶。Objective:To investigate the risk factors of lung cancer,also the relationship between lung cancer and GSTM1 gene polymorphism in Chinese population.Methods:Case-control studies on risk factors for lung cancer in Chinese population from January 1,2010 to August 1,2021 were searched in Pubmed,Embase,Web of Science,Cochrane Library,CNKI,CBM,VIP and Wanfang databases.NOS scale was used to screen literatures,then risk factors related to lung cancer were extracted and Meta-analysis was performed using ReviewManager5.3 and Stata16.0 software from 2010 to 2021.Results:A total of 48 literatures and 45904 subjects were included.After excluding the studies on impact heterogeneity,the fixed effect model was applied to obtain the Meta-analysis results:Smoking OR(95%CI)=3.29(3.02~3.57),passive smoking OR(95%CI)=2.31(2.03~2.62),family tumor history OR(95%CI)=4.36(3.30~5.77),regular physical exercise OR(95%CI)=0.41(0.34~0.48),fruits and vegetables OR(95%CI)=0.41(0.35~0.48),tea OR(95%CI)=0.66(0.60~0.73),history of respiratory diseases OR(95%CI)=2.89(2.24~3.73),depression OR(95%CI)=2.78(2.25~3.44),cooking fume OR(95%CI)=3.45(2.73~4.35),polluting factories nearby OR(95%CI)=1.87(1.55~2.26),GSTM1 null OR(95%CI)=1.87(1.66~2.11).Conclusion:The main risk factors of lung cancer in China from 2010 to 2021 included:Smoking,passive smoking,family history of cancer,history of respiratory diseases,emotional depression,cooking fume exposure,polluting factories nearby and GSTM1 null.The protective factors included:Regular physical exercise,eating vegetables and fruits frequently,drinking tea.

关 键 词：肺癌 危险因素 GSTM1 基因多态性 META分析 

分 类 号：R734.2[医药卫生—肿瘤]