草酸艾司西酞普兰联合认知干预改善产后抑郁症患者抑郁情绪及生活质量的临床效果  

Clinical effect of escitalopram oxalate combined with cognitive intervention in improving depression and quality of life in patients with postpartum depression

作　　者：郑志超 ZHENG Zhichao(Psychological Clinic,the Second Affiliated Hospital of Xiamen Medical College,Fujian Province,Xiamen 361021,China)

机构地区：[1]厦门医学院附属第二医院心理门诊,福建省厦门市361021

出　　处：《临床合理用药杂志》2022年第28期8-11,15,共5页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察草酸艾司西酞普兰联合认知干预改善产后抑郁症患者抑郁情绪及生活质量的临床效果。方法选取2019年1月-2021年3月厦门医学院附属第二医院收治的产后抑郁症患者400例,以入院顺序奇偶数分为观察组和对照组,每组200例。对照组给予认知干预,观察组给予草酸艾司西酞普兰联合认知干预,2组患者均治疗42 d。比较2组患者临床疗效、治疗前后抑郁自评量表(SDS)评分、神经递质[5-羟色胺(5-HT)、去甲肾上腺素(NE)、脑源性神经营养因子(BDNF)]水平、生活质量评分及不良反应。结果治疗42 d后,观察组患者治疗总有效率为94.00%,高于对照组的88.00%(χ^(2)=4.396,P=0.036);2组患者SDS评分均低于治疗前,且观察组低于对照组(P<0.01);2组患者5-HT、NE及BDNF水平均高于治疗前,且观察组高于对照组(P<0.05);2组患者活力、生理机能、生理职能、躯体疼痛、情感职能、社会职能、精神健康及总体健康评分均高于治疗前,且观察组高于对照组(P<0.05);观察组患者治疗期间出现食欲变化9例、失眠5例,不良反应总发生率为7.00%(14/200),但不良反应症状轻微,对疗程无影响。结论草酸艾司西酞普兰联合认知干预改善产后抑郁症患者抑郁情绪及生活质量的临床效果较好,可改善患者抑郁程度及神经递质分泌状态,提高生活质量,值得应用。Objective To observe the clinical effect of escitalopram oxalate combined with cognitive intervention in improving depression and quality of life in patients with postpartum depression.Methods A total of 400 patients with postpartum depression who were admitted to the Second Affiliated Hospital of Xiamen Medical College from January 2019 to March 2021 were selected,they were divided into observation group and control group according to the odd-even method of admission order,with 200 cases in each group.The control group was given cognitive intervention,and the observation group was given escitalopram oxalate combined with cognitive intervention,both groups were treated for 42 days.The clinical efficacy,self-rating depression scale(SDS)scores,neurotransmitter[5-serotonin(5-HT),norepinephrine(NE),brain-derived neurotrophic factor(BDNF)],quality of life scores and adverse reactions were compared between the two groups before and after treatment.Results After 42 days of treatment,the total effective rate of patients in the observation group was 94.00%,which was higher than 88.00%in the control group(χ^(2)=4.396,P=0.036);The SDS scores of both groups were lower than those before treatment,and the observation group was lower than the control group(P<0.01);The levels of 5-HT,NE and BDNF in both groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05);The scores of vitality,physiological function,physiological function,physical pain,emotional function,social function,mental health and overall health of patients in the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05);During the treatment period,there were 9 cases of changes in appetite and 5 cases of insomnia in the observation group,the total incidence of adverse reactions was 7.00%(14/200),but the symptoms of adverse reactions were mild and had no effect on the course of treatment.Conclusion The clinical effect of escitalopram oxalate combined

关 键 词：产后抑郁症 草酸艾司西酞普兰 抑郁情绪 生活质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]