肠道菌群视角下非酒精性脂肪性肝病的治疗策略  

Treatment Strategy of Nonalcoholic Fatty Liver Disease Targeting the Intestinal Microbiota

作　　者：傅伟强 周剑波 吴雄健[2] 黄才斌[2] FU Weiqiang;ZHOU Jianbo;WU Xiongjian;HUANG Caibin(The First Clinical Medical College of Gannan Medical University,Ganzhou 341000,China;Department of Gastroenterology,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]赣南医学院第一临床医学院,江西省赣州市341000 [2]赣南医学院第一附属医院消化内科,江西省赣州市341000

出　　处：《中国全科医学》2023年第6期742-748,共7页Chinese General Practice

基　　金：江西省自然科学基金资助项目(20202BAB206009)——LncRNA NEAT1诱导线粒体功能紊乱/氧化应激诱发肝纤维化的机制研究。

摘　　要：非酒精性脂肪性肝病(NAFLD)是最常见的慢性肝脏疾病,其疾病谱主要包括非酒精性肝脂肪变、非酒精性脂肪性肝炎(NASH)、肝硬化及肝细胞癌(HCC)。近年研究揭示肠-肝轴与NAFLD发生、发展相关,运动、饮食、微生态制剂、抗生素、粪菌移植、噬菌体等干预措施均可以通过改变肠道菌群缓解NAFLD。本文综述了肠道菌群与NAFLD的关系和作用机制及以调整肠道菌群为NAFLD治疗靶点的研究进展,发现肠道菌群与NAFLD密切相关,调控肠道菌群可作为NAFLD治疗的新靶点,将为临床医师治疗NAFLD提供新的思路和参考。Nonalcoholic fatty liver disease(NAFLD),the most common chronic liver disease,represents a spectrum of nonalcoholic hepatic steatosis,nonalcoholic steatohepatitis,liver cirrhosis and hepatocellular carcinoma.Recent studies have revealed that the gut-liver axis is associated with the development of NAFLD.Intervention measures such as exercise,diet,microecological preparations,antibiotics,fecal microbiota transplantation and bacteriophage can alleviate NAFLD by improving intestinal microbiota.We reviewed recent advances in the relationship and mechanism between intestinal microbiota and NAFLD as well as treatment of NAFLD targeting the intestinal microbiota,and summarized that intestinal microbiota is closely related to NAFLD,and the regulation of intestinal microbiota can be used as a new target for NAFLD treatment,which will provide new ideas and references for clinicians in the diagnosis and treatment of NAFLD.

关 键 词：非酒精性脂肪性肝病 胃肠道微生物组 肠道菌群 治疗 代谢综合征 微生态制剂 粪菌移植 

分 类 号：R575[医药卫生—消化系统]