抑酸药物预防恶性肿瘤化疗所致消化道毒副作用疗效的Meta分析  

Efficacy of gastric acid suppressants in the prevention of gastrointestinal toxicity caused by chemotherapy for malignant tumors:a Meta analysis

作　　者：陈景耀 胡懿芝 王丹蕊 郝腾飞 李明哲[1] 方素芬 Chen Jingyao;Hu Yizhi;Wang Danrui;Hao Tengfei;Li Mingzhe;Fang Sufen(Digestive Medicine Center,the Seventh Affiliated Hospital of Sun Yat-sen University,ShenZhen 518107,GuangDong,China;Sun Yat-sen University School of Medicine,ShenZhen,518107,GuangDong,China)

机构地区：[1]中山大学附属第七医院消化医学中心,广东深圳518107 [2]中山大学医学院,广东深圳518107

出　　处：《消化肿瘤杂志（电子版）》2022年第3期285-290,共6页Journal of Digestive Oncology(Electronic Version)

基　　金：深圳市科技计划项目(基础研究专项)(JCYJ20190809142807444)。

摘　　要：目的对比抑酸药物预防恶性肿瘤化疗所致消化道毒副作用的疗效。方法检索Pubmed、Embase、Cochrane、CMB、万方等数据库中抑酸药物预防恶性肿瘤化疗所致消化道毒副作用疗效的随机对照研究,根据纳入及排除标准筛选文献。从文献中提取数据后,使用RevMan 5.4软件进行分析。结果共8篇文献859例化疗患者纳入本研究,包括胃癌、结肠癌、乳腺癌、肺癌等,其中接受抑酸药物组484例,未接受抑酸药物组375例。Meta分析结果显示,抑酸药物可改善恶性肿瘤化疗所致恶心(P<0.05,OR=0.31,95%CI为0.17-0.55)、呕吐(P<0.05,OR=0.27,95%CI:0.16~0.47)、上腹痛或烧心(P<0.05-OR=0.37-95%CI:0.20~0.93)及食欲减退(P=0.007,OR=0.26-95%CI:0.10~0.69),但不能改善化疗所致腹泻(P=0.48,OR=0.22,95%CI:0~14.06)。结论抑酸药物的使用能预防恶性肿瘤化疗患者的恶心、呕吐、上腹痛或烧心、食欲减退等症状的发生,但不能预防化疗所致腹泻。Objective To compare the efficacy of gastric acid suppressants in the prevention of gastrointestinal toxicity caused by chemotherapy for malignant tumors.Method The literature was retrieved from Pubmed,Embase,Cochrane,CMB and Wanfang databases.The literature should be a randomized controlled study comparing the efficacy of gastric acid suppressants in preventing gastrointestinal toxicity caused by chemotherapy for malignant tumors.Literature was screened according to inclusion and exclusion criteria.The data were extracted and analyzed with RevMan 5.4 software.Result A total of 8 articles,including 859 patients with malignant tumor undergoing chemotherapy,were included in the study,including gastric cancer,colon cancer,breast cancer,lung cancer,etc.Among them,484 patients were treated with gastric acid suppressants and 375 patients were not.Meta analysis results showed that gastric acid suppressants could significantly reduce nausea(P<0.05,OR=0.31,95%CI:0.17-0.55),vomiting(P<0.05,OR=0.27,95%CI:0.16-0.47),epigastric pain or heartburn(P<0.05,OR=0.37,95%CI:0.20-0.93)and loss of appetite(P=0.007,OR=0.26,95%CI:0.10-0.69)caused by chemotherapy in malignant tumors,but could not reduce diarrhea(P=0.48,OR=0.22,95%CI:0-14.06).Conclusion Gastric acid suppressants can prevent nausea,vomiting,epigastric pain or heartburn,loss of appetite in patients with malignant tumor undergoing chemotherapy,but can't prevent diarrhea caused by chemotherapy.

关 键 词：恶性肿瘤 化疗 抑酸药物 META分析 

分 类 号：R730.5[医药卫生—肿瘤]