Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis  

作　　者：Yun-Juan Nie Shuo-Hua Wu Ying-Hua Xuan Gen Yan 

机构地区：[1]Department of Basic Medicine,Wuxi School of Medicine,Jiangnan University,Wuxi 214000,Jiangsu,China [2]Department of Radiology,the Second Affiliated Hospital,Medical College of Shantou University,Shantou 515000,Guangdong,China [3]Department of Basic Medicine,Xiamen Medical College,Xiamen 361000,Fujian,China [4]Department of Radiology,the Second Affiliated Hospital of Xiamen Medical College,Xiamen 361000,Fujian,China

出　　处：《Military Medical Research》2022年第5期618-627,共10页军事医学研究（英文版）

基　　金：Natural Science Foundation of Jiangsu Province(BK20180616);the Joint Funds for the Health and Education of Fujian Province(2019-WJ-31);the Institute of Respiratory Diseases,Xiamen Medical College(HXJB-15).

摘　　要：Idiopathic pulmonary fibrosis(IPF)is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function.Chronic inflammation has been demonstrated to be the pathological basis of fibrosis.Emerging studies have revealed that most interleukin-17(IL-17)isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity.Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes,including the initiation and exacerbation of IPF.Here,we aim to provide an overview of IL-17 family members in the pathogenesis of IPF.

关 键 词：Interleukin-17(IL-17)family IL-17 receptor INFLAMMATION Idiopathic pulmonary fibrosis 

分 类 号：R563[医药卫生—呼吸系统]